Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion
Purpose. The main objective of the study was to create a mathematical model that describes the melatonin circadian secretion and, then the functionality of the model was tested by a comparison of the melatonin secretions in children with and without epilepsy. Material and Methods. The patients were...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/3861461 |
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| author | Justyna Paprocka Marek Kijonka Marcin Pęcka Maria Sokół |
| author_facet | Justyna Paprocka Marek Kijonka Marcin Pęcka Maria Sokół |
| author_sort | Justyna Paprocka |
| collection | DOAJ |
| description | Purpose. The main objective of the study was to create a mathematical model that describes the melatonin circadian secretion and, then the functionality of the model was tested by a comparison of the melatonin secretions in children with and without epilepsy. Material and Methods. The patients were divided into the epilepsy group (EG, n=52) and the comparison group (CG, n=30). The melatonin level was assessed by a radioimmunoassay method. The diurnal melatonin secretion was described using a nonlinear least squares method. Spearman’s rank correlation coefficient was chosen to estimate the dependence of the acquired data. The model reproduces blood concentration profiles and its parameters were statistically analyzed using the Mann-Whitney-Wilcoxon test and logistic regression. Results. The correlation analysis performed for the EG and CG groups showed moderate correlations between age and the melatonin secretion model parameters. Patients with epilepsy are characterized by an increased phase shift of melatonin release. |
| format | Article |
| id | doaj-art-d863d49b2eab447aa892ba52bfbb1a6a |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-d863d49b2eab447aa892ba52bfbb1a6a2025-02-03T05:49:44ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/38614613861461Melatonin in Epilepsy: A New Mathematical Model of Diurnal SecretionJustyna Paprocka0Marek Kijonka1Marcin Pęcka2Maria Sokół3Department of Paediatrics and Developmental Age Neurology, School of Medicine in Katowice, Medical University of Silesia, Ulica Medyków 16, 40-752 Katowice, PolandDepartment of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Ulica Wybrzeże Armii Krajowej 15, 44-101 Gliwice, PolandFaculty of Automatic Control, Electronics and Computer Science Biomedical Engineering, Silesian University of Technology, Ulica Akademicka 2A, 44-100 Gliwice, PolandDepartment of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Ulica Wybrzeże Armii Krajowej 15, 44-101 Gliwice, PolandPurpose. The main objective of the study was to create a mathematical model that describes the melatonin circadian secretion and, then the functionality of the model was tested by a comparison of the melatonin secretions in children with and without epilepsy. Material and Methods. The patients were divided into the epilepsy group (EG, n=52) and the comparison group (CG, n=30). The melatonin level was assessed by a radioimmunoassay method. The diurnal melatonin secretion was described using a nonlinear least squares method. Spearman’s rank correlation coefficient was chosen to estimate the dependence of the acquired data. The model reproduces blood concentration profiles and its parameters were statistically analyzed using the Mann-Whitney-Wilcoxon test and logistic regression. Results. The correlation analysis performed for the EG and CG groups showed moderate correlations between age and the melatonin secretion model parameters. Patients with epilepsy are characterized by an increased phase shift of melatonin release.http://dx.doi.org/10.1155/2016/3861461 |
| spellingShingle | Justyna Paprocka Marek Kijonka Marcin Pęcka Maria Sokół Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion International Journal of Endocrinology |
| title | Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion |
| title_full | Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion |
| title_fullStr | Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion |
| title_full_unstemmed | Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion |
| title_short | Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion |
| title_sort | melatonin in epilepsy a new mathematical model of diurnal secretion |
| url | http://dx.doi.org/10.1155/2016/3861461 |
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