Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine
Abstract A key unanswered question in migraine neurobiology concerns the mechanisms that make the brain of migraineurs susceptible to cortical spreading depression (CSD, a spreading depolarization that underlies migraine aura and may trigger the migraine pain mechanisms). Important insights into thi...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | The Journal of Headache and Pain |
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| Online Access: | https://doi.org/10.1186/s10194-025-01948-x |
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| author | Daniela Pietrobon K.C. Brennan |
| author_facet | Daniela Pietrobon K.C. Brennan |
| author_sort | Daniela Pietrobon |
| collection | DOAJ |
| description | Abstract A key unanswered question in migraine neurobiology concerns the mechanisms that make the brain of migraineurs susceptible to cortical spreading depression (CSD, a spreading depolarization that underlies migraine aura and may trigger the migraine pain mechanisms). Important insights into this question can be obtained by studying the mechanisms of facilitation of CSD initiation in genetic mouse models of the disease. These models, all generated from families with hereditary migraine, allow the investigation of the functional consequences of disease-causing mutations at the molecular, cellular, synaptic and neural circuit levels. In this review, after describing the available genetic mouse models of migraine, which all share increased susceptibility to experimentally induced CSD, we will discuss the functional alterations in their cerebral cortex and the mechanisms underlying the facilitation of CSD initiation in their cortex, as well as the insights that these mechanisms may give into the mechanisms of initiation of spontaneous CSDs in migraine. |
| format | Article |
| id | doaj-art-d83f5530b1cc428394062d9d13756ae0 |
| institution | Kabale University |
| issn | 1129-2377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj-art-d83f5530b1cc428394062d9d13756ae02025-02-02T12:34:39ZengBMCThe Journal of Headache and Pain1129-23772025-01-0126111710.1186/s10194-025-01948-xMechanisms underlying CSD initiation implicated by genetic mouse models of migraineDaniela Pietrobon0K.C. Brennan1Department of Biomedical Sciences and Padova Neuroscience Center, University of PadovaDepartment of Neurology, University of UtahAbstract A key unanswered question in migraine neurobiology concerns the mechanisms that make the brain of migraineurs susceptible to cortical spreading depression (CSD, a spreading depolarization that underlies migraine aura and may trigger the migraine pain mechanisms). Important insights into this question can be obtained by studying the mechanisms of facilitation of CSD initiation in genetic mouse models of the disease. These models, all generated from families with hereditary migraine, allow the investigation of the functional consequences of disease-causing mutations at the molecular, cellular, synaptic and neural circuit levels. In this review, after describing the available genetic mouse models of migraine, which all share increased susceptibility to experimentally induced CSD, we will discuss the functional alterations in their cerebral cortex and the mechanisms underlying the facilitation of CSD initiation in their cortex, as well as the insights that these mechanisms may give into the mechanisms of initiation of spontaneous CSDs in migraine.https://doi.org/10.1186/s10194-025-01948-xSpreading depolarizationFamilial hemiplegic migraineMigraine with auraGlutamateNMDA receptorCaV2.1 channel |
| spellingShingle | Daniela Pietrobon K.C. Brennan Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine The Journal of Headache and Pain Spreading depolarization Familial hemiplegic migraine Migraine with aura Glutamate NMDA receptor CaV2.1 channel |
| title | Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine |
| title_full | Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine |
| title_fullStr | Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine |
| title_full_unstemmed | Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine |
| title_short | Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine |
| title_sort | mechanisms underlying csd initiation implicated by genetic mouse models of migraine |
| topic | Spreading depolarization Familial hemiplegic migraine Migraine with aura Glutamate NMDA receptor CaV2.1 channel |
| url | https://doi.org/10.1186/s10194-025-01948-x |
| work_keys_str_mv | AT danielapietrobon mechanismsunderlyingcsdinitiationimplicatedbygeneticmousemodelsofmigraine AT kcbrennan mechanismsunderlyingcsdinitiationimplicatedbygeneticmousemodelsofmigraine |