The Notch Pathway in Breast Cancer Progression
Objective. Notch signaling pathway is a vital parameter of the mammalian vascular system. In this review, the authors summarize the current knowledge about the impact of the Notch signaling pathway in breast cancer progression and the therapeutic role of Notch’s inhibition. Methods. The available li...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2018/2415489 |
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| _version_ | 1832558830019411968 |
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| author | Emmanuel N. Kontomanolis Sofia Kalagasidou Stamatia Pouliliou Xanthoula Anthoulaki Nikolaos Georgiou Valentinos Papamanolis Zacharias N. Fasoulakis |
| author_facet | Emmanuel N. Kontomanolis Sofia Kalagasidou Stamatia Pouliliou Xanthoula Anthoulaki Nikolaos Georgiou Valentinos Papamanolis Zacharias N. Fasoulakis |
| author_sort | Emmanuel N. Kontomanolis |
| collection | DOAJ |
| description | Objective. Notch signaling pathway is a vital parameter of the mammalian vascular system. In this review, the authors summarize the current knowledge about the impact of the Notch signaling pathway in breast cancer progression and the therapeutic role of Notch’s inhibition. Methods. The available literature in MEDLINE, PubMed, and Scopus, regarding the role of the Notch pathway in breast cancer progression was searched for related articles from about 1973 to 2017 including terms such as “Notch,” “Breast Cancer,” and “Angiogenesis.” Results. Notch signaling controls the differentiation of breast epithelial cells during normal development. Studies confirm that the Notch pathway has a major participation in breast cancer progression through overexpression and/or abnormal genetic type expression of the notch receptors and ligands that determine angiogenesis. The cross-talk of Notch and estrogens, the effect of Notch in breast cancer stem cells formation, and the dependable Notch overexpression during breast tumorigenesis have been studied enough and undoubtedly linked to breast cancer development. The already applied therapeutic inhibition of Notch for breast cancer can drastically change the course of the disease. Conclusion. Current data prove that Notch pathway has a major participation and multiple roles during breast tumor progression. Inhibition of Notch receptors and ligands provides innovative therapeutic results and could become the therapy of choice in the next few years, even though further research is needed to reach safe conclusions. |
| format | Article |
| id | doaj-art-d83693d009ce4a478ede48f2bae6cf79 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d83693d009ce4a478ede48f2bae6cf792025-02-03T01:31:35ZengWileyThe Scientific World Journal2356-61401537-744X2018-01-01201810.1155/2018/24154892415489The Notch Pathway in Breast Cancer ProgressionEmmanuel N. Kontomanolis0Sofia Kalagasidou1Stamatia Pouliliou2Xanthoula Anthoulaki3Nikolaos Georgiou4Valentinos Papamanolis5Zacharias N. Fasoulakis6Department of Obstetrics and Gynecology, Democritus University of Thrace, 681 00 Alexandroupolis, GreeceDepartment of Obstetrics and Gynecology, Bodosakio General Hospital of Ptolemaida, 502 00 Ptolemaida, GreeceDepartment of Radiotherapy/Oncology, Democritus University of Thrace, 681 00 Alexandroupolis, GreeceDepartment of Obstetrics and Gynecology, Democritus University of Thrace, 681 00 Alexandroupolis, GreeceStoke Mandeville & Wycombe General Hospital, Buckinghamshire NHS Trust, UKDepartment of Obstetrics & Gynecology, General Hospital of Korinthos, 201 00 Korinthos, GreeceDepartment of Obstetrics and Gynecology, Democritus University of Thrace, 681 00 Alexandroupolis, GreeceObjective. Notch signaling pathway is a vital parameter of the mammalian vascular system. In this review, the authors summarize the current knowledge about the impact of the Notch signaling pathway in breast cancer progression and the therapeutic role of Notch’s inhibition. Methods. The available literature in MEDLINE, PubMed, and Scopus, regarding the role of the Notch pathway in breast cancer progression was searched for related articles from about 1973 to 2017 including terms such as “Notch,” “Breast Cancer,” and “Angiogenesis.” Results. Notch signaling controls the differentiation of breast epithelial cells during normal development. Studies confirm that the Notch pathway has a major participation in breast cancer progression through overexpression and/or abnormal genetic type expression of the notch receptors and ligands that determine angiogenesis. The cross-talk of Notch and estrogens, the effect of Notch in breast cancer stem cells formation, and the dependable Notch overexpression during breast tumorigenesis have been studied enough and undoubtedly linked to breast cancer development. The already applied therapeutic inhibition of Notch for breast cancer can drastically change the course of the disease. Conclusion. Current data prove that Notch pathway has a major participation and multiple roles during breast tumor progression. Inhibition of Notch receptors and ligands provides innovative therapeutic results and could become the therapy of choice in the next few years, even though further research is needed to reach safe conclusions.http://dx.doi.org/10.1155/2018/2415489 |
| spellingShingle | Emmanuel N. Kontomanolis Sofia Kalagasidou Stamatia Pouliliou Xanthoula Anthoulaki Nikolaos Georgiou Valentinos Papamanolis Zacharias N. Fasoulakis The Notch Pathway in Breast Cancer Progression The Scientific World Journal |
| title | The Notch Pathway in Breast Cancer Progression |
| title_full | The Notch Pathway in Breast Cancer Progression |
| title_fullStr | The Notch Pathway in Breast Cancer Progression |
| title_full_unstemmed | The Notch Pathway in Breast Cancer Progression |
| title_short | The Notch Pathway in Breast Cancer Progression |
| title_sort | notch pathway in breast cancer progression |
| url | http://dx.doi.org/10.1155/2018/2415489 |
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