Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology
The epithelial-mesenchymal transition (EMT) is a complex transformation process that induces local and distant progression of many malignant tumours. Due to its complex array of proteins that are dynamically over-/underexpressed during this process, proteomic technologies gained their place in the E...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/3565970 |
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| author | Monica Neagu Carolina Constantin Marinela Bostan Constantin Caruntu Simona Rebeca Ignat Sorina Dinescu Marieta Costache |
| author_facet | Monica Neagu Carolina Constantin Marinela Bostan Constantin Caruntu Simona Rebeca Ignat Sorina Dinescu Marieta Costache |
| author_sort | Monica Neagu |
| collection | DOAJ |
| description | The epithelial-mesenchymal transition (EMT) is a complex transformation process that induces local and distant progression of many malignant tumours. Due to its complex array of proteins that are dynamically over-/underexpressed during this process, proteomic technologies gained their place in the EMT research in the last years. Proteomics has identified new molecular pathways of this process and brought important insights to develop new therapy targets. Various proteomic tools and multiple combinations were developed in this area. Out of the proteomic technology armentarium, mass spectrometry and array technologies are the most used approaches. The main characteristics of the proteomic technology used in this domain are high throughput and detection of minute concentration in small samples. We present herein, using various proteomic technologies, the identification in cancer cell lines and in tumour tissue EMT-related proteins, proteins that are involved in the activation of different cellular pathways. Proteomics has brought besides standard EMT markers (e.g., cell-cell adhesion proteins and transcription factors) other future potential markers for improving diagnosis, monitoring evolution, and developing new therapy targets. Future will increase the proteomic role in clinical investigation and validation of EMT-related biomarkers. |
| format | Article |
| id | doaj-art-d833acc0da274208bae0e9c5f4d9b048 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-d833acc0da274208bae0e9c5f4d9b0482025-02-03T01:28:54ZengWileyAnalytical Cellular Pathology2210-71772210-71852019-01-01201910.1155/2019/35659703565970Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in OncologyMonica Neagu0Carolina Constantin1Marinela Bostan2Constantin Caruntu3Simona Rebeca Ignat4Sorina Dinescu5Marieta Costache6Department of Immunology, Victor Babes National Institute of Pathology, Bucharest 050096, RomaniaDepartment of Immunology, Victor Babes National Institute of Pathology, Bucharest 050096, RomaniaDepartment of Immunology, Victor Babes National Institute of Pathology, Bucharest 050096, RomaniaCarol Davila University of Medicine and Pharmacy, Bucharest 050474, RomaniaFaculty of Biology, University of Bucharest, Bucharest 76201, RomaniaFaculty of Biology, University of Bucharest, Bucharest 76201, RomaniaFaculty of Biology, University of Bucharest, Bucharest 76201, RomaniaThe epithelial-mesenchymal transition (EMT) is a complex transformation process that induces local and distant progression of many malignant tumours. Due to its complex array of proteins that are dynamically over-/underexpressed during this process, proteomic technologies gained their place in the EMT research in the last years. Proteomics has identified new molecular pathways of this process and brought important insights to develop new therapy targets. Various proteomic tools and multiple combinations were developed in this area. Out of the proteomic technology armentarium, mass spectrometry and array technologies are the most used approaches. The main characteristics of the proteomic technology used in this domain are high throughput and detection of minute concentration in small samples. We present herein, using various proteomic technologies, the identification in cancer cell lines and in tumour tissue EMT-related proteins, proteins that are involved in the activation of different cellular pathways. Proteomics has brought besides standard EMT markers (e.g., cell-cell adhesion proteins and transcription factors) other future potential markers for improving diagnosis, monitoring evolution, and developing new therapy targets. Future will increase the proteomic role in clinical investigation and validation of EMT-related biomarkers.http://dx.doi.org/10.1155/2019/3565970 |
| spellingShingle | Monica Neagu Carolina Constantin Marinela Bostan Constantin Caruntu Simona Rebeca Ignat Sorina Dinescu Marieta Costache Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology Analytical Cellular Pathology |
| title | Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology |
| title_full | Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology |
| title_fullStr | Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology |
| title_full_unstemmed | Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology |
| title_short | Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology |
| title_sort | proteomic technology lens for epithelial mesenchymal transition process identification in oncology |
| url | http://dx.doi.org/10.1155/2019/3565970 |
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