Antifungal Resistance and New Strategies to Control Fungal Infections
Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice. In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled. In this paper, after a brief overview of cu...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2012/713687 |
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| author | Patrick Vandeputte Selene Ferrari Alix T. Coste |
| author_facet | Patrick Vandeputte Selene Ferrari Alix T. Coste |
| author_sort | Patrick Vandeputte |
| collection | DOAJ |
| description | Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice. In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled. In this paper, after a brief overview of currently available antifungals, molecular mechanisms of antifungal resistance will be detailed. It appears that major mechanisms of resistance are essential due to the deregulation of antifungal resistance effector genes. This deregulation is a consequence of point mutations occurring in transcriptional regulators of these effector genes. Resistance can also follow the emergence of point mutations directly in the genes coding antifungal targets. In addition we further describe new strategies currently undertaken to discover alternative therapy targets and antifungals. Identification of new antifungals is essentially achieved by the screening of natural or synthetic chemical compound collections. Discovery of new putative antifungal targets is performed through genome-wide approaches for a better understanding of the human pathogenic fungi biology. |
| format | Article |
| id | doaj-art-d82ab58c8a48423e81ebd6c009044095 |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-d82ab58c8a48423e81ebd6c0090440952025-02-03T01:06:13ZengWileyInternational Journal of Microbiology1687-918X1687-91982012-01-01201210.1155/2012/713687713687Antifungal Resistance and New Strategies to Control Fungal InfectionsPatrick Vandeputte0Selene Ferrari1Alix T. Coste2Institute of Microbiology, University of Lausanne and University Hospital, Rue du Bugnon 48, 1011 Lausanne, SwitzerlandInstitute of Microbiology, University of Lausanne and University Hospital, Rue du Bugnon 48, 1011 Lausanne, SwitzerlandInstitute of Microbiology, University of Lausanne and University Hospital, Rue du Bugnon 48, 1011 Lausanne, SwitzerlandDespite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice. In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled. In this paper, after a brief overview of currently available antifungals, molecular mechanisms of antifungal resistance will be detailed. It appears that major mechanisms of resistance are essential due to the deregulation of antifungal resistance effector genes. This deregulation is a consequence of point mutations occurring in transcriptional regulators of these effector genes. Resistance can also follow the emergence of point mutations directly in the genes coding antifungal targets. In addition we further describe new strategies currently undertaken to discover alternative therapy targets and antifungals. Identification of new antifungals is essentially achieved by the screening of natural or synthetic chemical compound collections. Discovery of new putative antifungal targets is performed through genome-wide approaches for a better understanding of the human pathogenic fungi biology.http://dx.doi.org/10.1155/2012/713687 |
| spellingShingle | Patrick Vandeputte Selene Ferrari Alix T. Coste Antifungal Resistance and New Strategies to Control Fungal Infections International Journal of Microbiology |
| title | Antifungal Resistance and New Strategies to Control Fungal Infections |
| title_full | Antifungal Resistance and New Strategies to Control Fungal Infections |
| title_fullStr | Antifungal Resistance and New Strategies to Control Fungal Infections |
| title_full_unstemmed | Antifungal Resistance and New Strategies to Control Fungal Infections |
| title_short | Antifungal Resistance and New Strategies to Control Fungal Infections |
| title_sort | antifungal resistance and new strategies to control fungal infections |
| url | http://dx.doi.org/10.1155/2012/713687 |
| work_keys_str_mv | AT patrickvandeputte antifungalresistanceandnewstrategiestocontrolfungalinfections AT seleneferrari antifungalresistanceandnewstrategiestocontrolfungalinfections AT alixtcoste antifungalresistanceandnewstrategiestocontrolfungalinfections |