Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging
The development of fluorescent methods for the detection of metal ions is of great importance due to their diverse environmental and biological roles. Herein, a rhodamine 6G-based off-on fluorescent probe (L1) with a t-butyl pyrrole moiety as the recognition site was designed and synthesized. Photop...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/8130767 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566713319686144 |
|---|---|
| author | Zhihao Guo Xiuji Wang Pei Wei Yihua Gao Qin Li |
| author_facet | Zhihao Guo Xiuji Wang Pei Wei Yihua Gao Qin Li |
| author_sort | Zhihao Guo |
| collection | DOAJ |
| description | The development of fluorescent methods for the detection of metal ions is of great importance due to their diverse environmental and biological roles. Herein, a rhodamine 6G-based off-on fluorescent probe (L1) with a t-butyl pyrrole moiety as the recognition site was designed and synthesized. Photophysical studies show that L1 exhibits excellent sensitivity and selectivity towards Cu2+ to other metal ions in neutral acetonitrile aqueous media. Mechanism studies suggest that the recognition process may associate with a Cu2+ promoted hydrolysis reaction of L1. Furthermore, L1 has been successfully applied in fluorescence imaging of Cu2+ ion in living cells. |
| format | Article |
| id | doaj-art-d82a29e99e854c9eaaef5d606cf9c0ef |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-d82a29e99e854c9eaaef5d606cf9c0ef2025-02-03T01:03:28ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732019-01-01201910.1155/2019/81307678130767Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell ImagingZhihao Guo0Xiuji Wang1Pei Wei2Yihua Gao3Qin Li4Analysis Center, Guangdong Medical University, Dongguan 523808, ChinaAnalysis Center, Guangdong Medical University, Dongguan 523808, ChinaAnalysis Center, Guangdong Medical University, Dongguan 523808, ChinaAnalysis Center, Guangdong Medical University, Dongguan 523808, ChinaAnalysis Center, Guangdong Medical University, Dongguan 523808, ChinaThe development of fluorescent methods for the detection of metal ions is of great importance due to their diverse environmental and biological roles. Herein, a rhodamine 6G-based off-on fluorescent probe (L1) with a t-butyl pyrrole moiety as the recognition site was designed and synthesized. Photophysical studies show that L1 exhibits excellent sensitivity and selectivity towards Cu2+ to other metal ions in neutral acetonitrile aqueous media. Mechanism studies suggest that the recognition process may associate with a Cu2+ promoted hydrolysis reaction of L1. Furthermore, L1 has been successfully applied in fluorescence imaging of Cu2+ ion in living cells.http://dx.doi.org/10.1155/2019/8130767 |
| spellingShingle | Zhihao Guo Xiuji Wang Pei Wei Yihua Gao Qin Li Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging Journal of Analytical Methods in Chemistry |
| title | Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging |
| title_full | Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging |
| title_fullStr | Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging |
| title_full_unstemmed | Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging |
| title_short | Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging |
| title_sort | highly selective fluorescent probe for the detection of copper ii and its application in live cell imaging |
| url | http://dx.doi.org/10.1155/2019/8130767 |
| work_keys_str_mv | AT zhihaoguo highlyselectivefluorescentprobeforthedetectionofcopperiianditsapplicationinlivecellimaging AT xiujiwang highlyselectivefluorescentprobeforthedetectionofcopperiianditsapplicationinlivecellimaging AT peiwei highlyselectivefluorescentprobeforthedetectionofcopperiianditsapplicationinlivecellimaging AT yihuagao highlyselectivefluorescentprobeforthedetectionofcopperiianditsapplicationinlivecellimaging AT qinli highlyselectivefluorescentprobeforthedetectionofcopperiianditsapplicationinlivecellimaging |