Understanding whole person systems in brain-gut-microbiome research through ultra-high-field MRI imaging
The brain-gut-microbiome (BGM) axis regulates interoception, metabolism, and immunity, with dysfunction linked to IBS, obesity, and mood disorders. Ultra-high-field (UHF) MRI advances neural imaging, enhancing resolution of vagal and spinal circuits mediating gut-brain communication. UHF enables rea...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925003635 |
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| author | Tien S. Dong Kay Jann Danny J.J. Wang Arpana Church |
| author_facet | Tien S. Dong Kay Jann Danny J.J. Wang Arpana Church |
| author_sort | Tien S. Dong |
| collection | DOAJ |
| description | The brain-gut-microbiome (BGM) axis regulates interoception, metabolism, and immunity, with dysfunction linked to IBS, obesity, and mood disorders. Ultra-high-field (UHF) MRI advances neural imaging, enhancing resolution of vagal and spinal circuits mediating gut-brain communication. UHF enables real-time tracking of interventions like vagus nerve stimulation and probiotics, linking microbiome shifts to neural adaptations. Despite challenges like signal distortions, innovations in coil design are improving imaging fidelity. Integrating neuroimaging with multi-omic profiling fosters a systems-level approach, advancing personalized therapies for BGM disorders. This commentary underscores UHF MRI’s transformative potential in bridging neuroscience, microbiome science, and clinical applications. |
| format | Article |
| id | doaj-art-d828d71f1df2419a9f16547ba42dae10 |
| institution | OA Journals |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-d828d71f1df2419a9f16547ba42dae102025-08-20T02:36:16ZengElsevierNeuroImage1095-95722025-08-0131712136010.1016/j.neuroimage.2025.121360Understanding whole person systems in brain-gut-microbiome research through ultra-high-field MRI imagingTien S. Dong0Kay Jann1Danny J.J. Wang2Arpana Church3The Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Goodman-Luskine Microbiome Center, University of California, Los Angeles, Los Angeles, CA, USA; Corresponding author at: Goodman-Luskine Microbiome Center, University of California, Los Angeles, Los Angeles, CA, USA.Laboratory of Functional MRI Technology, Stevens Neuroimaging and Informatics Institute, University of Southern California, USALaboratory of Functional MRI Technology, Stevens Neuroimaging and Informatics Institute, University of Southern California, USAThe Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Goodman-Luskine Microbiome Center, University of California, Los Angeles, Los Angeles, CA, USAThe brain-gut-microbiome (BGM) axis regulates interoception, metabolism, and immunity, with dysfunction linked to IBS, obesity, and mood disorders. Ultra-high-field (UHF) MRI advances neural imaging, enhancing resolution of vagal and spinal circuits mediating gut-brain communication. UHF enables real-time tracking of interventions like vagus nerve stimulation and probiotics, linking microbiome shifts to neural adaptations. Despite challenges like signal distortions, innovations in coil design are improving imaging fidelity. Integrating neuroimaging with multi-omic profiling fosters a systems-level approach, advancing personalized therapies for BGM disorders. This commentary underscores UHF MRI’s transformative potential in bridging neuroscience, microbiome science, and clinical applications.http://www.sciencedirect.com/science/article/pii/S1053811925003635Ultra-high-field MRI7T MRIMulti-omicsBrain-gut-microbiom axis |
| spellingShingle | Tien S. Dong Kay Jann Danny J.J. Wang Arpana Church Understanding whole person systems in brain-gut-microbiome research through ultra-high-field MRI imaging NeuroImage Ultra-high-field MRI 7T MRI Multi-omics Brain-gut-microbiom axis |
| title | Understanding whole person systems in brain-gut-microbiome research through ultra-high-field MRI imaging |
| title_full | Understanding whole person systems in brain-gut-microbiome research through ultra-high-field MRI imaging |
| title_fullStr | Understanding whole person systems in brain-gut-microbiome research through ultra-high-field MRI imaging |
| title_full_unstemmed | Understanding whole person systems in brain-gut-microbiome research through ultra-high-field MRI imaging |
| title_short | Understanding whole person systems in brain-gut-microbiome research through ultra-high-field MRI imaging |
| title_sort | understanding whole person systems in brain gut microbiome research through ultra high field mri imaging |
| topic | Ultra-high-field MRI 7T MRI Multi-omics Brain-gut-microbiom axis |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925003635 |
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