Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources
Blood transfusions hold an indispensable part in the modern healthcare system. Up to date, the blood supply is largely dependent on donations. Unfortunately, collecting the clinical-grade blood products has become a challenging mission due to accelerated population aging, which not only increases th...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/9281329 |
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| _version_ | 1832564991420530688 |
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| author | Yoojin Seo Kyung-Hwa Shin Hyung Hoi Kim Hyung-Sik Kim |
| author_facet | Yoojin Seo Kyung-Hwa Shin Hyung Hoi Kim Hyung-Sik Kim |
| author_sort | Yoojin Seo |
| collection | DOAJ |
| description | Blood transfusions hold an indispensable part in the modern healthcare system. Up to date, the blood supply is largely dependent on donations. Unfortunately, collecting the clinical-grade blood products has become a challenging mission due to accelerated population aging, which not only increases the need for blood transfusions but also decreases the number of healthy donors. Moreover, individuals with severe hematological abnormalities or rare blood phenotypes need alternative therapeutic approaches instead of conventional blood transfusion. In these aspects, the concept of in vitro/ex vivo production of blood cells has been emerging and many attempts have been focused on manufacturing mature erythrocytes, so-called red blood cells (RBCs), the most common and important component among the blood derivatives. In this review, we provide a general overview regarding the current strategies for generating RBCs from various stem cell sources including pluripotent stem cells (PSCs) as well as circulating blood stem cells and the remaining challenges that must be overcome prior to their practical application. |
| format | Article |
| id | doaj-art-d8262572b5db474e815f5fda81d4e193 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-d8262572b5db474e815f5fda81d4e1932025-02-03T01:09:45ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/92813299281329Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse SourcesYoojin Seo0Kyung-Hwa Shin1Hyung Hoi Kim2Hyung-Sik Kim3Institute of Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan 50612, Republic of KoreaDepartment of Laboratory Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of KoreaDepartment of Laboratory Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of KoreaInstitute of Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan 50612, Republic of KoreaBlood transfusions hold an indispensable part in the modern healthcare system. Up to date, the blood supply is largely dependent on donations. Unfortunately, collecting the clinical-grade blood products has become a challenging mission due to accelerated population aging, which not only increases the need for blood transfusions but also decreases the number of healthy donors. Moreover, individuals with severe hematological abnormalities or rare blood phenotypes need alternative therapeutic approaches instead of conventional blood transfusion. In these aspects, the concept of in vitro/ex vivo production of blood cells has been emerging and many attempts have been focused on manufacturing mature erythrocytes, so-called red blood cells (RBCs), the most common and important component among the blood derivatives. In this review, we provide a general overview regarding the current strategies for generating RBCs from various stem cell sources including pluripotent stem cells (PSCs) as well as circulating blood stem cells and the remaining challenges that must be overcome prior to their practical application.http://dx.doi.org/10.1155/2019/9281329 |
| spellingShingle | Yoojin Seo Kyung-Hwa Shin Hyung Hoi Kim Hyung-Sik Kim Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources Stem Cells International |
| title | Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources |
| title_full | Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources |
| title_fullStr | Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources |
| title_full_unstemmed | Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources |
| title_short | Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources |
| title_sort | current advances in red blood cell generation using stem cells from diverse sources |
| url | http://dx.doi.org/10.1155/2019/9281329 |
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