Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma
Recurrent, advanced stage cutaneous squamous cell carcinoma (cSCC) is uncommon with limited publications on patient outcomes. A retrospective study including patients who underwent surgical resection for recurrent, advanced stage cSCC of the head and neck was performed (n=72). Data regarding tumor...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/972497 |
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| author | Nichole R. Dean Larissa Sweeny J. Scott Magnuson William R. Carroll Daniel Robinson Renee A. Desmond Eben L. Rosenthal |
| author_facet | Nichole R. Dean Larissa Sweeny J. Scott Magnuson William R. Carroll Daniel Robinson Renee A. Desmond Eben L. Rosenthal |
| author_sort | Nichole R. Dean |
| collection | DOAJ |
| description | Recurrent, advanced stage cutaneous squamous cell carcinoma (cSCC) is uncommon with limited publications on patient outcomes. A retrospective study including patients who underwent surgical resection for recurrent, advanced stage cSCC of the head and neck was performed (n=72). Data regarding tumor site, stage, treatment, parotid involvement, perineural invasion, positive margins, metastasis, and disease-free survival was analyzed. The majority of patients were male (85%) and presented with recurrent stage III (89%) cSCC. Two-year disease-free survival was 62% and decreased to 47% at 5 years. Parotid involvement, positive margins, nodal metastasis, or the presence of perineural invasion did not correlate with decreased survival (P>.05). Distant metastasis was a strong indicator of poor overall survival (P<.001). Adjuvant postoperative radiotherapy did not improve overall survival (P=.42). Overall survival was poor for patients with advanced recurrent cSCC despite the combined treatment with surgery and radiotherapy. |
| format | Article |
| id | doaj-art-d81f0784dc5b4beea0570d207c154436 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-d81f0784dc5b4beea0570d207c1544362025-02-03T06:08:23ZengWileyJournal of Skin Cancer2090-29052090-29132011-01-01201110.1155/2011/972497972497Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell CarcinomaNichole R. Dean0Larissa Sweeny1J. Scott Magnuson2William R. Carroll3Daniel Robinson4Renee A. Desmond5Eben L. Rosenthal6Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USADivision of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USADivision of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USADivision of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USADivision of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USADivision of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 25294, USADivision of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082,1670 University Boulevard, Birmingham, AL 35233, USARecurrent, advanced stage cutaneous squamous cell carcinoma (cSCC) is uncommon with limited publications on patient outcomes. A retrospective study including patients who underwent surgical resection for recurrent, advanced stage cSCC of the head and neck was performed (n=72). Data regarding tumor site, stage, treatment, parotid involvement, perineural invasion, positive margins, metastasis, and disease-free survival was analyzed. The majority of patients were male (85%) and presented with recurrent stage III (89%) cSCC. Two-year disease-free survival was 62% and decreased to 47% at 5 years. Parotid involvement, positive margins, nodal metastasis, or the presence of perineural invasion did not correlate with decreased survival (P>.05). Distant metastasis was a strong indicator of poor overall survival (P<.001). Adjuvant postoperative radiotherapy did not improve overall survival (P=.42). Overall survival was poor for patients with advanced recurrent cSCC despite the combined treatment with surgery and radiotherapy.http://dx.doi.org/10.1155/2011/972497 |
| spellingShingle | Nichole R. Dean Larissa Sweeny J. Scott Magnuson William R. Carroll Daniel Robinson Renee A. Desmond Eben L. Rosenthal Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma Journal of Skin Cancer |
| title | Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma |
| title_full | Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma |
| title_fullStr | Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma |
| title_full_unstemmed | Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma |
| title_short | Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma |
| title_sort | outcomes of recurrent head and neck cutaneous squamous cell carcinoma |
| url | http://dx.doi.org/10.1155/2011/972497 |
| work_keys_str_mv | AT nicholerdean outcomesofrecurrentheadandneckcutaneoussquamouscellcarcinoma AT larissasweeny outcomesofrecurrentheadandneckcutaneoussquamouscellcarcinoma AT jscottmagnuson outcomesofrecurrentheadandneckcutaneoussquamouscellcarcinoma AT williamrcarroll outcomesofrecurrentheadandneckcutaneoussquamouscellcarcinoma AT danielrobinson outcomesofrecurrentheadandneckcutaneoussquamouscellcarcinoma AT reneeadesmond outcomesofrecurrentheadandneckcutaneoussquamouscellcarcinoma AT ebenlrosenthal outcomesofrecurrentheadandneckcutaneoussquamouscellcarcinoma |