The Role of Galectins as Modulators of Metabolism and Inflammation
Galectins are β-galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to glycosylated proteins and lipids. In humans, th...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/9186940 |
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| author | Monica Fengsrud Brinchmann Deepti Manjari Patel Martin Haugmo Iversen |
| author_facet | Monica Fengsrud Brinchmann Deepti Manjari Patel Martin Haugmo Iversen |
| author_sort | Monica Fengsrud Brinchmann |
| collection | DOAJ |
| description | Galectins are β-galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to glycosylated proteins and lipids. In humans, there are 12 identified galectins, some with tissue-specific distribution. Galectins are found inside cells and in the nucleus, cytosol, and organelles, as well as extracellularly. Galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation. In the context of metabolic control and loss of the same in, for example, diabetes, galectin-1, -2, -3, -9, and -12 are especially interesting. This review presents information on galectins relevant to the control of inflammation and metabolism and the potential to target galectins for therapeutic purposes. |
| format | Article |
| id | doaj-art-d8099690a17d48f49c663876ff9dccdf |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d8099690a17d48f49c663876ff9dccdf2025-02-03T06:44:46ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/91869409186940The Role of Galectins as Modulators of Metabolism and InflammationMonica Fengsrud Brinchmann0Deepti Manjari Patel1Martin Haugmo Iversen2Faculty of Biosciences and Aquaculture, Nord University, 8049 Bodø, NorwayFaculty of Biosciences and Aquaculture, Nord University, 8049 Bodø, NorwayFaculty of Biosciences and Aquaculture, Nord University, 8049 Bodø, NorwayGalectins are β-galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to glycosylated proteins and lipids. In humans, there are 12 identified galectins, some with tissue-specific distribution. Galectins are found inside cells and in the nucleus, cytosol, and organelles, as well as extracellularly. Galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation. In the context of metabolic control and loss of the same in, for example, diabetes, galectin-1, -2, -3, -9, and -12 are especially interesting. This review presents information on galectins relevant to the control of inflammation and metabolism and the potential to target galectins for therapeutic purposes.http://dx.doi.org/10.1155/2018/9186940 |
| spellingShingle | Monica Fengsrud Brinchmann Deepti Manjari Patel Martin Haugmo Iversen The Role of Galectins as Modulators of Metabolism and Inflammation Mediators of Inflammation |
| title | The Role of Galectins as Modulators of Metabolism and Inflammation |
| title_full | The Role of Galectins as Modulators of Metabolism and Inflammation |
| title_fullStr | The Role of Galectins as Modulators of Metabolism and Inflammation |
| title_full_unstemmed | The Role of Galectins as Modulators of Metabolism and Inflammation |
| title_short | The Role of Galectins as Modulators of Metabolism and Inflammation |
| title_sort | role of galectins as modulators of metabolism and inflammation |
| url | http://dx.doi.org/10.1155/2018/9186940 |
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