Roseburia hominis improves host metabolism in diet-induced obesity
Next-generation live biotherapeutics are promising to aid the treatment of obesity and metabolic diseases. Here, we reported a novel anti-obesity probiotic candidate, Roseburia hominis, that was depleted in stool samples of obese subjects compared with lean controls, and its abundance was negatively...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2467193 |
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| _version_ | 1849716659961462784 |
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| author | Wenli Huang Wenyi Zhu Yu Lin Francis K. L. Chan Zhilu Xu Siew C. Ng |
| author_facet | Wenli Huang Wenyi Zhu Yu Lin Francis K. L. Chan Zhilu Xu Siew C. Ng |
| author_sort | Wenli Huang |
| collection | DOAJ |
| description | Next-generation live biotherapeutics are promising to aid the treatment of obesity and metabolic diseases. Here, we reported a novel anti-obesity probiotic candidate, Roseburia hominis, that was depleted in stool samples of obese subjects compared with lean controls, and its abundance was negatively correlated with body mass index and serum triglycerides. Supplementation of R. hominis prevented body weight gain and disorders of glucose and lipid metabolism, prevented fatty liver, inhibited white adipose tissue expansion and brown adipose tissue whitening in mice fed with high-fat diet, and boosted the abundance of lean-related species. The effects of R. hominis could be partially attributed to the production of nicotinamide riboside and upregulation of the Sirtuin1/mTOR signaling pathway. These results indicated that R. hominis is a promising candidate for the development of next-generation live biotherapeutics for the prevention of obesity and metabolic diseases. |
| format | Article |
| id | doaj-art-d805f827331a4fd1a0a7d863c86ba26e |
| institution | DOAJ |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-d805f827331a4fd1a0a7d863c86ba26e2025-08-20T03:12:56ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2467193Roseburia hominis improves host metabolism in diet-induced obesityWenli Huang0Wenyi Zhu1Yu Lin2Francis K. L. Chan3Zhilu Xu4Siew C. Ng5Microbiota I-Center (MagIC), Hong Kong, ChinaMicrobiota I-Center (MagIC), Hong Kong, ChinaMicrobiota I-Center (MagIC), Hong Kong, ChinaMicrobiota I-Center (MagIC), Hong Kong, ChinaMicrobiota I-Center (MagIC), Hong Kong, ChinaMicrobiota I-Center (MagIC), Hong Kong, ChinaNext-generation live biotherapeutics are promising to aid the treatment of obesity and metabolic diseases. Here, we reported a novel anti-obesity probiotic candidate, Roseburia hominis, that was depleted in stool samples of obese subjects compared with lean controls, and its abundance was negatively correlated with body mass index and serum triglycerides. Supplementation of R. hominis prevented body weight gain and disorders of glucose and lipid metabolism, prevented fatty liver, inhibited white adipose tissue expansion and brown adipose tissue whitening in mice fed with high-fat diet, and boosted the abundance of lean-related species. The effects of R. hominis could be partially attributed to the production of nicotinamide riboside and upregulation of the Sirtuin1/mTOR signaling pathway. These results indicated that R. hominis is a promising candidate for the development of next-generation live biotherapeutics for the prevention of obesity and metabolic diseases.https://www.tandfonline.com/doi/10.1080/19490976.2025.2467193Intestinal microbiologyObesityprobiotics |
| spellingShingle | Wenli Huang Wenyi Zhu Yu Lin Francis K. L. Chan Zhilu Xu Siew C. Ng Roseburia hominis improves host metabolism in diet-induced obesity Gut Microbes Intestinal microbiology Obesity probiotics |
| title | Roseburia hominis improves host metabolism in diet-induced obesity |
| title_full | Roseburia hominis improves host metabolism in diet-induced obesity |
| title_fullStr | Roseburia hominis improves host metabolism in diet-induced obesity |
| title_full_unstemmed | Roseburia hominis improves host metabolism in diet-induced obesity |
| title_short | Roseburia hominis improves host metabolism in diet-induced obesity |
| title_sort | roseburia hominis improves host metabolism in diet induced obesity |
| topic | Intestinal microbiology Obesity probiotics |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2467193 |
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