Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response
High-altitude deacclimatization syndrome (HADAS) is involved in hypoxia-reoxygenation injury and inflammatory response, induced a series of symptoms, and has emerged as a severe public health issue. Here, we investigated the mechanism as well as potential means to prevent HADAS using Shenqi pollen c...
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| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/4521231 |
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| author | Binfeng He Mingdong Hu Zhihui Liang Qianli Ma Yunhai Zi Zhiwei Dong Qi Li Yongjun Luo Guisheng Qian Liang Guo Kexiong Lin Zhenyu Liu Guansong Wang |
| author_facet | Binfeng He Mingdong Hu Zhihui Liang Qianli Ma Yunhai Zi Zhiwei Dong Qi Li Yongjun Luo Guisheng Qian Liang Guo Kexiong Lin Zhenyu Liu Guansong Wang |
| author_sort | Binfeng He |
| collection | DOAJ |
| description | High-altitude deacclimatization syndrome (HADAS) is involved in hypoxia-reoxygenation injury and inflammatory response, induced a series of symptoms, and has emerged as a severe public health issue. Here, we investigated the mechanism as well as potential means to prevent HADAS using Shenqi pollen capsules (SPCs) in subjects with HADAS in a multicenter, double-blinded, randomized, placebo-controlled study. All subjects were at the same high altitude (3650 m) for 4-8 months before returning to lower altitudes. Subjects (n=288) in 20 clusters were diagnosed with mild or moderate HADAS on the third day of the study. We randomly allocated 20 clusters of subjects (1 : 1) to receive SPCs or a placebo for 7 weeks, and they were then followed up to the 14th week. The primary endpoints were subjects’ HADAS scores recorded during the 14 weeks of follow-up. Compared with the placebo, SPC treatment significantly decreased the subjects’ HADAS scores and reduced the incidence of symptom persistence. SPC therapy also reduced the serum levels of CK, CK-MB, LDH, IL-17A, TNF-α, and miR-155 and elevated IL-10 and miR-21 levels. We thus demonstrate that SPCs effectively ameliorated HADAS symptoms in these subjects via suppression of the hypoxia-reoxygenation injury and inflammatory response. |
| format | Article |
| id | doaj-art-d7fc3b3f3ce946048bdca2dd058f6c81 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d7fc3b3f3ce946048bdca2dd058f6c812025-02-03T01:10:22ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/45212314521231Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory ResponseBinfeng He0Mingdong Hu1Zhihui Liang2Qianli Ma3Yunhai Zi4Zhiwei Dong5Qi Li6Yongjun Luo7Guisheng Qian8Liang Guo9Kexiong Lin10Zhenyu Liu11Guansong Wang12Institute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, ChinaInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, ChinaBethune International Peace Hospital of PLA, Shijiazhuang, Hebei 050000, ChinaInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, ChinaInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, ChinaCenter for Disease Control and Prevention of Zhengzhou City and First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, ChinaInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, ChinaCollege of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, ChinaInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, ChinaInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, ChinaDepartment of Respiration, Tongren City People’s Hospital, Guizhou 554300, ChinaDepartment of Emergency, The First Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, ChinaHigh-altitude deacclimatization syndrome (HADAS) is involved in hypoxia-reoxygenation injury and inflammatory response, induced a series of symptoms, and has emerged as a severe public health issue. Here, we investigated the mechanism as well as potential means to prevent HADAS using Shenqi pollen capsules (SPCs) in subjects with HADAS in a multicenter, double-blinded, randomized, placebo-controlled study. All subjects were at the same high altitude (3650 m) for 4-8 months before returning to lower altitudes. Subjects (n=288) in 20 clusters were diagnosed with mild or moderate HADAS on the third day of the study. We randomly allocated 20 clusters of subjects (1 : 1) to receive SPCs or a placebo for 7 weeks, and they were then followed up to the 14th week. The primary endpoints were subjects’ HADAS scores recorded during the 14 weeks of follow-up. Compared with the placebo, SPC treatment significantly decreased the subjects’ HADAS scores and reduced the incidence of symptom persistence. SPC therapy also reduced the serum levels of CK, CK-MB, LDH, IL-17A, TNF-α, and miR-155 and elevated IL-10 and miR-21 levels. We thus demonstrate that SPCs effectively ameliorated HADAS symptoms in these subjects via suppression of the hypoxia-reoxygenation injury and inflammatory response.http://dx.doi.org/10.1155/2019/4521231 |
| spellingShingle | Binfeng He Mingdong Hu Zhihui Liang Qianli Ma Yunhai Zi Zhiwei Dong Qi Li Yongjun Luo Guisheng Qian Liang Guo Kexiong Lin Zhenyu Liu Guansong Wang Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response Journal of Immunology Research |
| title | Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response |
| title_full | Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response |
| title_fullStr | Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response |
| title_full_unstemmed | Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response |
| title_short | Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response |
| title_sort | efficacy of shenqi pollen capsules for high altitude deacclimatization syndrome via suppression of the reoxygenation injury and inflammatory response |
| url | http://dx.doi.org/10.1155/2019/4521231 |
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