GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation

GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation

Abstract Intrauterine exposure to hyperglycemia increases the risk of hypertension disorders in the offspring. Vascular dysfunction has a critical role in hypertension development. This study aimed to investigate the effects of GDM on human umbilical vein (HUV) constriction and the underlying mechan...

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Bibliographic Details
Main Authors: Yun He, Qin Ni, Cuiyun Zhang, liulin Zhou, Shuang Li, Yu Tao, Lanhua Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Acetylcholine
CHRM3
CACNA1C
Gestational diabetes mellitus
Human umbilical vein
Online Access:https://doi.org/10.1038/s41598-025-10576-z
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