Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy

Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy

IntroductionRheumatoid arthritis (RA) primarily affects the joints but can also affect multiple organs and profoundly impacts patients’ ability to carry out daily activities, mental health, and life expectancy. Current treatments for RA are limited in terms of duration, efficacy, and adverse effects...

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Bibliographic Details
Main Authors: Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
AAV
RA
intra-articular
systemic
soluble
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1527858/full
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