Confinement by Liquid‐Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb‐Based Migration

Confinement by Liquid‐Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb‐Based Migration

Abstract Leukocytes forge paths through interstitial spaces by exerting forces to overcome confining mechanical pressures provided by surrounding cells. While such mechanical cues regulate leukocyte motility, engineering an in vitro system that models the deformable cellular environment encountered...

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Main Authors: Jonathan H. Schrope, Adam Horn, Kaitlyn Lazorchak, Clyde W. Tinnen, Jack J Stevens, Mehtab Farooqui, Tanner Robertson, Jiayi Li, David Bennin, Terry Juang, Adeel Ahmed, Chao Li, Anna Huttenlocher, David J Beebe
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
cell confinement
cell migration
immunology
mechanobiology
microfluidics
neutrophils
Online Access:https://doi.org/10.1002/advs.202414024
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https://doi.org/10.1002/advs.202414024

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