The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules
Aim. Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth facto...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/3145234 |
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| author | Ayfer Altas Fatih Kuzu Dilek Arpaci Mustafa Unal Murat Can Figen Barut Furuzan Kokturk Sevil Uygun Ilikhan Taner Bayraktaroglu |
| author_facet | Ayfer Altas Fatih Kuzu Dilek Arpaci Mustafa Unal Murat Can Figen Barut Furuzan Kokturk Sevil Uygun Ilikhan Taner Bayraktaroglu |
| author_sort | Ayfer Altas |
| collection | DOAJ |
| description | Aim. Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases. Materials and Methods. In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules. After performing FNAB, IGF-1 and IGFBP-3 levels were determined in blood and aspiration samples. Results. The serum levels of IGF-1 (232.8 ± 12.9 ng/ml) and IGFBP-3 (4.8 μg/ml) were found significantly higher than that of the intranodular IGF-1 (39.1 ng/ml) and intranodular IGFBP-3 levels (0.173 μg/ml) (p<0.01). Intranodular levels of IGF-1 and IGFBP-3 were higher in subjects with multinodular thyroid gland than those of subjects with solitary nodules (p=0.043). A positive correlation between the nodule size and the serum IGFBP-3 levels was detected (p=0.042, r=0.23). Conclusion. This study demonstrated the possible role of both IGF-1 and IGFBP-3 in the growth and the formation of multinodularity of thyroid nodules. |
| format | Article |
| id | doaj-art-d7b27d72ecbd4c6ca406997cf8afc3b3 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-d7b27d72ecbd4c6ca406997cf8afc3b32025-02-03T06:44:46ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/31452343145234The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid NodulesAyfer Altas0Fatih Kuzu1Dilek Arpaci2Mustafa Unal3Murat Can4Figen Barut5Furuzan Kokturk6Sevil Uygun Ilikhan7Taner Bayraktaroglu8Department of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, Zonguldak, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, Zonguldak, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, Zonguldak, TurkeyDepartment of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, Zonguldak, TurkeyDepartment of Biochemistry, Faculty of Medicine, Bulent Ecevit University, Zonguldak, TurkeyDepartment of Pathology, Faculty of Medicine, Bulent Ecevit University, Zonguldak, TurkeyDepartment of Biostatistics, Faculty of Medicine, Bulent Ecevit University, Zonguldak, TurkeyDepartment of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, Zonguldak, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, Zonguldak, TurkeyAim. Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases. Materials and Methods. In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules. After performing FNAB, IGF-1 and IGFBP-3 levels were determined in blood and aspiration samples. Results. The serum levels of IGF-1 (232.8 ± 12.9 ng/ml) and IGFBP-3 (4.8 μg/ml) were found significantly higher than that of the intranodular IGF-1 (39.1 ng/ml) and intranodular IGFBP-3 levels (0.173 μg/ml) (p<0.01). Intranodular levels of IGF-1 and IGFBP-3 were higher in subjects with multinodular thyroid gland than those of subjects with solitary nodules (p=0.043). A positive correlation between the nodule size and the serum IGFBP-3 levels was detected (p=0.042, r=0.23). Conclusion. This study demonstrated the possible role of both IGF-1 and IGFBP-3 in the growth and the formation of multinodularity of thyroid nodules.http://dx.doi.org/10.1155/2017/3145234 |
| spellingShingle | Ayfer Altas Fatih Kuzu Dilek Arpaci Mustafa Unal Murat Can Figen Barut Furuzan Kokturk Sevil Uygun Ilikhan Taner Bayraktaroglu The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules International Journal of Endocrinology |
| title | The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules |
| title_full | The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules |
| title_fullStr | The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules |
| title_full_unstemmed | The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules |
| title_short | The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules |
| title_sort | clinical values of insulin like growth factor 1 and insulin like growth factor binding protein 3 levels in blood and thyroid nodules |
| url | http://dx.doi.org/10.1155/2017/3145234 |
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