Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient
Uric acid accumulates in renal failure and is thought to be a uremic toxin—that is, higher levels of uric acid are more damaging to the kidneys. Urate crystals can precipitate in the kidney tubules, cause urate stones, and promote inflammatory changes in the renal interstitium and vascular endotheli...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2016/9106935 |
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| author | Lynda Ann Frassetto Suzanne Gibson |
| author_facet | Lynda Ann Frassetto Suzanne Gibson |
| author_sort | Lynda Ann Frassetto |
| collection | DOAJ |
| description | Uric acid accumulates in renal failure and is thought to be a uremic toxin—that is, higher levels of uric acid are more damaging to the kidneys. Urate crystals can precipitate in the kidney tubules, cause urate stones, and promote inflammatory changes in the renal interstitium and vascular endothelium. Uric acid is also a small non-protein-bound molecule and therefore easily dialyzable. Here, we present the case of an anuric hemodialysis patient with severe tophaceous gout who regained some renal function and whose gout burden significantly decreased resulting in marked improvement in functional status using a new gout medication, febuxostat, and increased frequency of dialysis. |
| format | Article |
| id | doaj-art-d79c8751803c4e118fc4a1b2531464b5 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-d79c8751803c4e118fc4a1b2531464b52025-02-03T01:29:12ZengWileyCase Reports in Nephrology2090-66412090-665X2016-01-01201610.1155/2016/91069359106935Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis PatientLynda Ann Frassetto0Suzanne Gibson1Department of Medicine/Nephrology, University of California, San Francisco, San Francisco, CA 94143, USADivision of Nephrology, University of California, San Francisco, San Francisco, CA 94143, USAUric acid accumulates in renal failure and is thought to be a uremic toxin—that is, higher levels of uric acid are more damaging to the kidneys. Urate crystals can precipitate in the kidney tubules, cause urate stones, and promote inflammatory changes in the renal interstitium and vascular endothelium. Uric acid is also a small non-protein-bound molecule and therefore easily dialyzable. Here, we present the case of an anuric hemodialysis patient with severe tophaceous gout who regained some renal function and whose gout burden significantly decreased resulting in marked improvement in functional status using a new gout medication, febuxostat, and increased frequency of dialysis.http://dx.doi.org/10.1155/2016/9106935 |
| spellingShingle | Lynda Ann Frassetto Suzanne Gibson Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient Case Reports in Nephrology |
| title | Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient |
| title_full | Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient |
| title_fullStr | Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient |
| title_full_unstemmed | Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient |
| title_short | Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient |
| title_sort | febuxostat and increased dialysis as a treatment for severe tophaceous gout in a hemodialysis patient |
| url | http://dx.doi.org/10.1155/2016/9106935 |
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