A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives
Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the TGF-β family of ligands and are unequivocally involved in regulating stem cell behavior. Appropriate regulation of canonical BMP signaling is critical for the development and homeostasis of numerous human organ systems, as...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7290686 |
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| _version_ | 1832562640592830464 |
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| author | Jonathan W. Lowery Brice Brookshire Vicki Rosen |
| author_facet | Jonathan W. Lowery Brice Brookshire Vicki Rosen |
| author_sort | Jonathan W. Lowery |
| collection | DOAJ |
| description | Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the TGF-β family of ligands and are unequivocally involved in regulating stem cell behavior. Appropriate regulation of canonical BMP signaling is critical for the development and homeostasis of numerous human organ systems, as aberrations in the BMP pathway or its regulation are increasingly associated with diverse human pathologies. In this review, we provide a wide-perspective on strategies that increase or decrease BMP signaling. We briefly outline the current FDA-approved approaches, highlight emerging next-generation technologies, and postulate prospective avenues for future investigation. We also detail how activating other pathways may indirectly modulate BMP signaling, with a particular emphasis on the relationship between the BMP and Activin/TGF-β pathways. |
| format | Article |
| id | doaj-art-d78405a4253e49d88eaea12eed8fc5c5 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-d78405a4253e49d88eaea12eed8fc5c52025-02-03T01:22:12ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/72906867290686A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future PerspectivesJonathan W. Lowery0Brice Brookshire1Vicki Rosen2Division of Biomedical Science, Marian University College of Osteopathic Medicine, Indianapolis, IN 46222, USADivision of Biomedical Science, Marian University College of Osteopathic Medicine, Indianapolis, IN 46222, USADepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USABone morphogenetic proteins (BMPs) constitute the largest subdivision of the TGF-β family of ligands and are unequivocally involved in regulating stem cell behavior. Appropriate regulation of canonical BMP signaling is critical for the development and homeostasis of numerous human organ systems, as aberrations in the BMP pathway or its regulation are increasingly associated with diverse human pathologies. In this review, we provide a wide-perspective on strategies that increase or decrease BMP signaling. We briefly outline the current FDA-approved approaches, highlight emerging next-generation technologies, and postulate prospective avenues for future investigation. We also detail how activating other pathways may indirectly modulate BMP signaling, with a particular emphasis on the relationship between the BMP and Activin/TGF-β pathways.http://dx.doi.org/10.1155/2016/7290686 |
| spellingShingle | Jonathan W. Lowery Brice Brookshire Vicki Rosen A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives Stem Cells International |
| title | A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives |
| title_full | A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives |
| title_fullStr | A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives |
| title_full_unstemmed | A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives |
| title_short | A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives |
| title_sort | survey of strategies to modulate the bone morphogenetic protein signaling pathway current and future perspectives |
| url | http://dx.doi.org/10.1155/2016/7290686 |
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