TMPRSS4 as a prognostic biomarker after gastric cancer surgery in a multicenter retrospective study

TMPRSS4 as a prognostic biomarker after gastric cancer surgery in a multicenter retrospective study

Abstract Transmembrane protease serine 4 (TMPRSS4) is a member of the type II transmembrane serine protease family known to be upregulated in many malignancies. We previously showed that TMPRSS4 may be a prognostic biomarker and therapeutic target for gastric cancer (GC), especially in stage III. In...

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Bibliographic Details
Main Authors: Hirofumi Tazawa, Shinji Hato, Shigefumi Yoshino, Shinya Otsuka, Atsusi Takeno, Kazuhiro Toyota, Hiromitsu Moriya, Isao Nozaki, Koji Tanakaya, Hideaki Uchiyama, Akihisa Saito, Kazuya Kuraoka, Takeshi Kato, Takahisa Suzuki, Hirotaka Tashiro
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Gastric cancer
Transmembrane serine protease 4
Biomarker
Overall survival
Progression free survival
Online Access:https://doi.org/10.1038/s41598-025-93422-6
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