Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011–2018
Introduction Currently, knowledge on relationships between blood concen-trations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease (CKD) is lacking. The aim of the study was to ex-plore the relationships between blood concentrations of heavy metals and the occ...
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Termedia Publishing House
2024-12-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/Relationships-between-blood-concentrations-of-cadmium-lead-mercury-selenium-and-manganese,181508,0,2.html |
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| author | Shenghua Yao Dan Xu |
| author_facet | Shenghua Yao Dan Xu |
| author_sort | Shenghua Yao |
| collection | DOAJ |
| description | Introduction
Currently, knowledge on relationships between blood concen-trations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease (CKD) is lacking. The aim of the study was to ex-plore the relationships between blood concentrations of heavy metals and the occurrence of CKD.
Material and methods
Data from the National Health and Nutrition Examination Survey (NHANES) 2011–2018 were used to investigate the relationships between blood concentrations of mercury, lead, cadmium, selenium, and manganese and the occurrence of CKD using a weighted logistic recession analysis. Restrictive cubic spline analysis was applied to assess the dose–response relationship. The sample population was divided into four groups based on the quartiles of heavy metal concentrations (Q1: < 25th percentile, Q2: 25th–50th percentile, Q3: 50th–75th percentile, Q4: ≥ 75th percentile).
Results
A total of 15,450 participants were included. With regard to blood lead concentrations, the odds ratio (OR) for CKD in Q4 relative to Q1 was 1.36 (95% confidence interval [CI]: 1.20–1.61), indicating an increased oc-currence of CKD in Q4. With regard to blood cadmium concentrations, the ORs for CKD in Q2, Q3, and Q4 were 1.06 (95% CI: 0.92–1.22), 1.21 (95% CI: 1.05–1.39), and 1.52 (95% CI: 1.31–1.76), respectively. Non-linear dose–response relationships were identified between blood cadmium and lead concentrations and the occurrence of CKD. Further, blood lead and cadmium concentrations showed statistically significant interaction effects with age, hypertension, and obesity on CKD.
Conclusions
Higher cadmium and lead concentrations in blood are asso-ciated with increased occurrence of CKD, especially in older adults, people with hypertension, and people with obesity. |
| format | Article |
| id | doaj-art-d7795803a03b4ca6967b9ef41b42e3e0 |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-d7795803a03b4ca6967b9ef41b42e3e02025-01-27T10:45:12ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-12-012061822183010.5114/aoms/181508181508Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011–2018Shenghua Yao0Dan Xu1Department of Nephrology, Yuyao People’s Hospital, Ningbo, ChinaDepartment of Geriatrics, Yuyao People’s Hospital, Ningbo, ChinaIntroduction Currently, knowledge on relationships between blood concen-trations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease (CKD) is lacking. The aim of the study was to ex-plore the relationships between blood concentrations of heavy metals and the occurrence of CKD. Material and methods Data from the National Health and Nutrition Examination Survey (NHANES) 2011–2018 were used to investigate the relationships between blood concentrations of mercury, lead, cadmium, selenium, and manganese and the occurrence of CKD using a weighted logistic recession analysis. Restrictive cubic spline analysis was applied to assess the dose–response relationship. The sample population was divided into four groups based on the quartiles of heavy metal concentrations (Q1: < 25th percentile, Q2: 25th–50th percentile, Q3: 50th–75th percentile, Q4: ≥ 75th percentile). Results A total of 15,450 participants were included. With regard to blood lead concentrations, the odds ratio (OR) for CKD in Q4 relative to Q1 was 1.36 (95% confidence interval [CI]: 1.20–1.61), indicating an increased oc-currence of CKD in Q4. With regard to blood cadmium concentrations, the ORs for CKD in Q2, Q3, and Q4 were 1.06 (95% CI: 0.92–1.22), 1.21 (95% CI: 1.05–1.39), and 1.52 (95% CI: 1.31–1.76), respectively. Non-linear dose–response relationships were identified between blood cadmium and lead concentrations and the occurrence of CKD. Further, blood lead and cadmium concentrations showed statistically significant interaction effects with age, hypertension, and obesity on CKD. Conclusions Higher cadmium and lead concentrations in blood are asso-ciated with increased occurrence of CKD, especially in older adults, people with hypertension, and people with obesity.https://www.archivesofmedicalscience.com/Relationships-between-blood-concentrations-of-cadmium-lead-mercury-selenium-and-manganese,181508,0,2.htmlmetalsdiseaseepidemiology |
| spellingShingle | Shenghua Yao Dan Xu Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011–2018 Archives of Medical Science metals disease epidemiology |
| title | Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011–2018 |
| title_full | Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011–2018 |
| title_fullStr | Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011–2018 |
| title_full_unstemmed | Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011–2018 |
| title_short | Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011–2018 |
| title_sort | relationships between blood concentrations of cadmium lead mercury selenium and manganese and the risk of chronic kidney disease a cross sectional study based on nhanes 2011 2018 |
| topic | metals disease epidemiology |
| url | https://www.archivesofmedicalscience.com/Relationships-between-blood-concentrations-of-cadmium-lead-mercury-selenium-and-manganese,181508,0,2.html |
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