Impact of HPV Catch-Up Vaccination on High-Grade Cervical Lesions (CIN2+) Among Women Aged 26–30 in Northern Norway
Background/Objectives: Human papillomavirus (HPV) is the primary cause of high-grade cervical lesions and cervical cancer worldwide. In Norway, HPV vaccination was introduced in 2009 for seventh-grade girls and extended through a catch-up program from 2016 to 2019 for women born between 1991 and 199...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2076-393X/13/1/96 |
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| author | Amanda Sørensen Jørgensen Gunnar Skov Simonsen Sveinung Wergeland Sørbye |
| author_facet | Amanda Sørensen Jørgensen Gunnar Skov Simonsen Sveinung Wergeland Sørbye |
| author_sort | Amanda Sørensen Jørgensen |
| collection | DOAJ |
| description | Background/Objectives: Human papillomavirus (HPV) is the primary cause of high-grade cervical lesions and cervical cancer worldwide. In Norway, HPV vaccination was introduced in 2009 for seventh-grade girls and extended through a catch-up program from 2016 to 2019 for women born between 1991 and 1996. This study evaluates the impact of the catch-up vaccination program on the incidence of HPV and high-grade cervical lesions in Troms and Finnmark. Methods: We analyzed data from 40,617 women aged 26 to 30 who underwent cervical screening between 2009 and 2023 in Troms and Finnmark, including 1850 women with high-grade cervical lesions (CIN2+) on biopsy. Using linear regression, we assessed trends in high-grade lesion incidence per 1000 screened women and the association between vaccination status and HPV-16/18 incidence. Results: Between 2017 and 2023, the incidence of high-grade cervical lesions significantly decreased: CIN2+ decreased by 33.4%, and CIN3+ decreased by 63.4%. Significant reductions in HPV-16/18-associated high-grade cervical lesions were observed among vaccinated women, with the proportion of CIN2+ cases due to HPV-16 and 18 decreasing from 56.8% in 2017 to 40.7% in 2023, reflecting a 55.8% reduction in the absolute number of cases caused by these high-risk HPV types. Comparing unvaccinated women aged 25–26 in 2016 and vaccinated women in 2023, HPV-16 incidence decreased from 5.1% to 0.1%, and HPV-18 incidence decreased from 3.3% to 0.0%. Conclusions: The catch-up vaccination program significantly reduced the incidence of HPV-16/18 and high-grade cervical lesions in Troms and Finnmark, even with the lower vaccination coverage observed in the catch-up program. These findings demonstrate the effectiveness of HPV vaccination programs in reducing HPV infections and associated cervical lesions. |
| format | Article |
| id | doaj-art-d7702acfc9f347b9a081e9a665151205 |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-d7702acfc9f347b9a081e9a6651512052025-01-24T13:51:56ZengMDPI AGVaccines2076-393X2025-01-011319610.3390/vaccines13010096Impact of HPV Catch-Up Vaccination on High-Grade Cervical Lesions (CIN2+) Among Women Aged 26–30 in Northern NorwayAmanda Sørensen Jørgensen0Gunnar Skov Simonsen1Sveinung Wergeland Sørbye2Department of Medical Biology, UiT The Arctic University of Norway, 9037 Tromsø, NorwayDepartment of Medical Biology, UiT The Arctic University of Norway, 9037 Tromsø, NorwayDepartment of Clinical Pathology, University Hospital of North Norway, 9038 Tromsø, NorwayBackground/Objectives: Human papillomavirus (HPV) is the primary cause of high-grade cervical lesions and cervical cancer worldwide. In Norway, HPV vaccination was introduced in 2009 for seventh-grade girls and extended through a catch-up program from 2016 to 2019 for women born between 1991 and 1996. This study evaluates the impact of the catch-up vaccination program on the incidence of HPV and high-grade cervical lesions in Troms and Finnmark. Methods: We analyzed data from 40,617 women aged 26 to 30 who underwent cervical screening between 2009 and 2023 in Troms and Finnmark, including 1850 women with high-grade cervical lesions (CIN2+) on biopsy. Using linear regression, we assessed trends in high-grade lesion incidence per 1000 screened women and the association between vaccination status and HPV-16/18 incidence. Results: Between 2017 and 2023, the incidence of high-grade cervical lesions significantly decreased: CIN2+ decreased by 33.4%, and CIN3+ decreased by 63.4%. Significant reductions in HPV-16/18-associated high-grade cervical lesions were observed among vaccinated women, with the proportion of CIN2+ cases due to HPV-16 and 18 decreasing from 56.8% in 2017 to 40.7% in 2023, reflecting a 55.8% reduction in the absolute number of cases caused by these high-risk HPV types. Comparing unvaccinated women aged 25–26 in 2016 and vaccinated women in 2023, HPV-16 incidence decreased from 5.1% to 0.1%, and HPV-18 incidence decreased from 3.3% to 0.0%. Conclusions: The catch-up vaccination program significantly reduced the incidence of HPV-16/18 and high-grade cervical lesions in Troms and Finnmark, even with the lower vaccination coverage observed in the catch-up program. These findings demonstrate the effectiveness of HPV vaccination programs in reducing HPV infections and associated cervical lesions.https://www.mdpi.com/2076-393X/13/1/96HPV vaccinationcatch-up immunizationcervical intraepithelial neoplasia (CIN)HPV types 16 and 18cervical cancer preventionpublic health impact |
| spellingShingle | Amanda Sørensen Jørgensen Gunnar Skov Simonsen Sveinung Wergeland Sørbye Impact of HPV Catch-Up Vaccination on High-Grade Cervical Lesions (CIN2+) Among Women Aged 26–30 in Northern Norway Vaccines HPV vaccination catch-up immunization cervical intraepithelial neoplasia (CIN) HPV types 16 and 18 cervical cancer prevention public health impact |
| title | Impact of HPV Catch-Up Vaccination on High-Grade Cervical Lesions (CIN2+) Among Women Aged 26–30 in Northern Norway |
| title_full | Impact of HPV Catch-Up Vaccination on High-Grade Cervical Lesions (CIN2+) Among Women Aged 26–30 in Northern Norway |
| title_fullStr | Impact of HPV Catch-Up Vaccination on High-Grade Cervical Lesions (CIN2+) Among Women Aged 26–30 in Northern Norway |
| title_full_unstemmed | Impact of HPV Catch-Up Vaccination on High-Grade Cervical Lesions (CIN2+) Among Women Aged 26–30 in Northern Norway |
| title_short | Impact of HPV Catch-Up Vaccination on High-Grade Cervical Lesions (CIN2+) Among Women Aged 26–30 in Northern Norway |
| title_sort | impact of hpv catch up vaccination on high grade cervical lesions cin2 among women aged 26 30 in northern norway |
| topic | HPV vaccination catch-up immunization cervical intraepithelial neoplasia (CIN) HPV types 16 and 18 cervical cancer prevention public health impact |
| url | https://www.mdpi.com/2076-393X/13/1/96 |
| work_keys_str_mv | AT amandasørensenjørgensen impactofhpvcatchupvaccinationonhighgradecervicallesionscin2amongwomenaged2630innorthernnorway AT gunnarskovsimonsen impactofhpvcatchupvaccinationonhighgradecervicallesionscin2amongwomenaged2630innorthernnorway AT sveinungwergelandsørbye impactofhpvcatchupvaccinationonhighgradecervicallesionscin2amongwomenaged2630innorthernnorway |