RBFOX1 Regulates Calcium Signaling and Enhances SERCA2 Translation

RBFOX1 Regulates Calcium Signaling and Enhances SERCA2 Translation

RBFOX1 is an RNA-binding protein that regulates alternative splicing and RNA processing in the neurons, skeletal muscle, and heart. We intended to define the role of RBFOX1 in regulating calcium homeostasis to maintain normal cardiac function. We generated cardiomyocyte-specific <i>Rbfox1</...

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Bibliographic Details
Main Authors: Sadiq Umar, Wuqiang Zhu, Fernando Souza-Neto, Ingrid Bender, Steven C. Wu, Chastity L. Healy, Timothy D. O’Connell, Jop H. van Berlo
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
calcium signaling
heart failure
gene regulation
cardiac hypertrophy
Online Access:https://www.mdpi.com/2073-4409/14/9/664
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