Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy
Background:. Chemotherapy-induced peripheral neuropathy (CIPN) affects 29%–68% of patients undergoing anticancer treatments within the first month. Traditional cryotherapy methods, such as frozen gloves, can pose risks. This study evaluates the cool-water electric circulation seat (CECS), which main...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2025-01-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006423 |
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| author | Yuki Matsui, MD, PhD Hirotaka Kishi, MD Chihiro Matsui, MD Jun Morita, MD, PhD Hiroshi Mizuno, MD, PhD Hatan Mortada, MBBS Haruaki Sasaki, MD, PhD Takashi Fukagai, MD, PhD |
| author_facet | Yuki Matsui, MD, PhD Hirotaka Kishi, MD Chihiro Matsui, MD Jun Morita, MD, PhD Hiroshi Mizuno, MD, PhD Hatan Mortada, MBBS Haruaki Sasaki, MD, PhD Takashi Fukagai, MD, PhD |
| author_sort | Yuki Matsui, MD, PhD |
| collection | DOAJ |
| description | Background:. Chemotherapy-induced peripheral neuropathy (CIPN) affects 29%–68% of patients undergoing anticancer treatments within the first month. Traditional cryotherapy methods, such as frozen gloves, can pose risks. This study evaluates the cool-water electric circulation seat (CECS), which maintains a constant 15°C, as a safer alternative.
Methods:. In this prospective study, 21 healthy Japanese adults underwent 2.5 hours of hand cooling at 15°C, reflecting the standard duration of taxane anticancer drug administration. Microcirculation was evaluated using videocapillaroscopy before and after cooling.
Results:. Results showed significant reductions in blood vessel area and altered red blood cell movement postcooling. Finger temperature and vascular area decreased significantly (P < 0.001), and red blood cell movement changed significantly, with most cells shifting from slow (52.4%) or fast (47.6%) movement before cooling to slow (23.8%) or immobile (76.2%) afterward (P < 0.001). Thirty minutes postcooling, 38.1% of participants reported temporary redness, and 28.6% reported pain, both resolving by the next day.
Conclusions:. The CECS effectively provides secure cooling, offering a promising approach for CIPN prevention without frostbite risk. These findings highlight the potential advantages of CECS in sustained cooling therapy for CIPN prevention. |
| format | Article |
| id | doaj-art-d7505f04ba6741f0b0336433ef0d8151 |
| institution | Kabale University |
| issn | 2169-7574 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj-art-d7505f04ba6741f0b0336433ef0d81512025-01-24T09:19:58ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742025-01-01131e642310.1097/GOX.0000000000006423202501000-00034Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral NeuropathyYuki Matsui, MD, PhD0Hirotaka Kishi, MD1Chihiro Matsui, MD2Jun Morita, MD, PhD3Hiroshi Mizuno, MD, PhD4Hatan Mortada, MBBS5Haruaki Sasaki, MD, PhD6Takashi Fukagai, MD, PhD7From the * Department of Urology, Showa University School of Medicine; Tokyo, JapanFrom the * Department of Urology, Showa University School of Medicine; Tokyo, Japan‡ Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo, JapanFrom the * Department of Urology, Showa University School of Medicine; Tokyo, Japan‡ Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo, Japan§ Division of Plastic Surgery, Department of Surgery, King Saud University Medical City, King Saud University and Department of Plastic Surgery and Burn Unit, King Saud Medical City, Riyadh, Saudi Arabia¶ Department of Urology, Showa University Fujigaoka Hospital, Kanagawa, Japan.From the * Department of Urology, Showa University School of Medicine; Tokyo, JapanBackground:. Chemotherapy-induced peripheral neuropathy (CIPN) affects 29%–68% of patients undergoing anticancer treatments within the first month. Traditional cryotherapy methods, such as frozen gloves, can pose risks. This study evaluates the cool-water electric circulation seat (CECS), which maintains a constant 15°C, as a safer alternative. Methods:. In this prospective study, 21 healthy Japanese adults underwent 2.5 hours of hand cooling at 15°C, reflecting the standard duration of taxane anticancer drug administration. Microcirculation was evaluated using videocapillaroscopy before and after cooling. Results:. Results showed significant reductions in blood vessel area and altered red blood cell movement postcooling. Finger temperature and vascular area decreased significantly (P < 0.001), and red blood cell movement changed significantly, with most cells shifting from slow (52.4%) or fast (47.6%) movement before cooling to slow (23.8%) or immobile (76.2%) afterward (P < 0.001). Thirty minutes postcooling, 38.1% of participants reported temporary redness, and 28.6% reported pain, both resolving by the next day. Conclusions:. The CECS effectively provides secure cooling, offering a promising approach for CIPN prevention without frostbite risk. These findings highlight the potential advantages of CECS in sustained cooling therapy for CIPN prevention.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006423 |
| spellingShingle | Yuki Matsui, MD, PhD Hirotaka Kishi, MD Chihiro Matsui, MD Jun Morita, MD, PhD Hiroshi Mizuno, MD, PhD Hatan Mortada, MBBS Haruaki Sasaki, MD, PhD Takashi Fukagai, MD, PhD Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy Plastic and Reconstructive Surgery, Global Open |
| title | Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy |
| title_full | Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy |
| title_fullStr | Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy |
| title_full_unstemmed | Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy |
| title_short | Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy |
| title_sort | novel frostbite cooling device for real time assessment and prevention of chemotherapy induced peripheral neuropathy |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006423 |
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