Endothelial function/damage markers and NGAL – intraoperative assessment in blood specimens obtained from different sampling sites during open repair of abdominal aortic aneurysm
Introduction: The aim of the study was to investigate the dynamics of changes in the concentrations of neutrophil gelatinase-associated lipocalin (NGAL), an acute kidney injury biomarker, as well as endothelial function/damage markers including P-selectin, intercellular adhesion molecule 1 (ICAM-1),...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Śląski Uniwersytet Medyczny w Katowicach
2025-02-01
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| Series: | Annales Academiae Medicae Silesiensis |
| Subjects: | |
| Online Access: | https://annales.sum.edu.pl/Endothelial-function-damage-markers-and-NGAL-intraoperative-assessment-in-blood-specimens,199671,0,2.html |
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| Summary: | Introduction: The aim of the study was to investigate the dynamics of changes in the concentrations of neutrophil gelatinase-associated lipocalin (NGAL), an acute kidney injury biomarker, as well as endothelial function/damage markers including P-selectin, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and the von Willebrand factor (vWf) in blood specimens obtained from different sampling sites during open abdominal aortic aneurysm (AAA) repair.
Material and methods: Thirty-three patients qualified for elective open repair (ORe) were enrolled in the study. All the mentioned parameters were determined in blood samples drawn from: 1) the cubital vein prior to surgery, and then intraoperatively, 2) the renal vein before aortic cross-clamping, 3) renal vein immediately before aortic cross-clamp removal, 4) cubital vein immediately before aortic cross-clamp removal, 5) inferior vena cava immediately before aortic cross-clamp removal, 6) renal vein at 5 minutes after aortic cross-clamp removal and 7) cubital vein at 5 minutes after aortic cross-clamp removal.
Results: The P-selectin, ICAM-1 and VCAM-1 concentrations were found to have decreased in the cubital samples drawn immediately before aortic clamp removal and at 5 minutes after aortic clamp removal vs the pre-surgery cubital samples. Rapid changes during surgery were also found in the NGAL, vWf and VCAM-1 concentrations.
Conclusions: The obtained results seem to evidence the development of an inflammatory response while open AAA repair is still in progress. |
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| ISSN: | 1734-025X |