The Maternal Brain: An Organ with Peripartal Plasticity
The time of pregnancy, birth, and lactation, is characterized by numerous specific alterations in several systems of the maternal body. Peripartum-associated changes in physiology and behavior, as well as their underlying molecular mechanisms, have been the focus of research since decades, but are...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/574159 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560904370126848 |
|---|---|
| author | Katharina Maria Hillerer Volker Rudolf Jacobs Thorsten Fischer Ludwig Aigner |
| author_facet | Katharina Maria Hillerer Volker Rudolf Jacobs Thorsten Fischer Ludwig Aigner |
| author_sort | Katharina Maria Hillerer |
| collection | DOAJ |
| description | The time of pregnancy, birth, and lactation, is characterized by numerous specific alterations in several systems of the maternal body. Peripartum-associated changes in physiology and behavior, as well as their underlying molecular mechanisms, have been the focus of research since decades, but are still far from being entirely understood. Also, there is growing evidence that pregnancy and lactation are associated with a variety of alterations in neural plasticity, including adult neurogenesis, functional and structural synaptic plasticity, and dendritic remodeling in different brain regions. All of the mentioned changes are not only believed to be a prerequisite for the proper fetal and neonatal development, but moreover to be crucial for the physiological and mental health of the mother. The underlying mechanisms apparently need to be under tight control, since in cases of dysregulation, a certain percentage of women develop disorders like preeclampsia or postpartum mood and anxiety disorders during the course of pregnancy and lactation.
This review describes common peripartum adaptations in physiology and behavior. Moreover, it concentrates on different forms of peripartum-associated plasticity including changes in neurogenesis and their possible underlying molecular mechanisms. Finally, consequences of malfunction in those systems are discussed. |
| format | Article |
| id | doaj-art-d72fdbe1d8ab4e4c8fde5744d671a2da |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-d72fdbe1d8ab4e4c8fde5744d671a2da2025-02-03T01:26:27ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/574159574159The Maternal Brain: An Organ with Peripartal PlasticityKatharina Maria Hillerer0Volker Rudolf Jacobs1Thorsten Fischer2Ludwig Aigner3Department of Obstetrics and Gynecology, Salzburger Landeskrankenhaus (SALK), Paracelsus Medical University, Müllner Hauptstrasse 48/Strubergasse 21, 5020 Salzburg, AustriaDepartment of Obstetrics and Gynecology, Salzburger Landeskrankenhaus (SALK), Paracelsus Medical University, Müllner Hauptstrasse 48/Strubergasse 21, 5020 Salzburg, AustriaDepartment of Obstetrics and Gynecology, Salzburger Landeskrankenhaus (SALK), Paracelsus Medical University, Müllner Hauptstrasse 48/Strubergasse 21, 5020 Salzburg, AustriaInstitute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, AustriaThe time of pregnancy, birth, and lactation, is characterized by numerous specific alterations in several systems of the maternal body. Peripartum-associated changes in physiology and behavior, as well as their underlying molecular mechanisms, have been the focus of research since decades, but are still far from being entirely understood. Also, there is growing evidence that pregnancy and lactation are associated with a variety of alterations in neural plasticity, including adult neurogenesis, functional and structural synaptic plasticity, and dendritic remodeling in different brain regions. All of the mentioned changes are not only believed to be a prerequisite for the proper fetal and neonatal development, but moreover to be crucial for the physiological and mental health of the mother. The underlying mechanisms apparently need to be under tight control, since in cases of dysregulation, a certain percentage of women develop disorders like preeclampsia or postpartum mood and anxiety disorders during the course of pregnancy and lactation. This review describes common peripartum adaptations in physiology and behavior. Moreover, it concentrates on different forms of peripartum-associated plasticity including changes in neurogenesis and their possible underlying molecular mechanisms. Finally, consequences of malfunction in those systems are discussed.http://dx.doi.org/10.1155/2014/574159 |
| spellingShingle | Katharina Maria Hillerer Volker Rudolf Jacobs Thorsten Fischer Ludwig Aigner The Maternal Brain: An Organ with Peripartal Plasticity Neural Plasticity |
| title | The Maternal Brain: An Organ with Peripartal Plasticity |
| title_full | The Maternal Brain: An Organ with Peripartal Plasticity |
| title_fullStr | The Maternal Brain: An Organ with Peripartal Plasticity |
| title_full_unstemmed | The Maternal Brain: An Organ with Peripartal Plasticity |
| title_short | The Maternal Brain: An Organ with Peripartal Plasticity |
| title_sort | maternal brain an organ with peripartal plasticity |
| url | http://dx.doi.org/10.1155/2014/574159 |
| work_keys_str_mv | AT katharinamariahillerer thematernalbrainanorganwithperipartalplasticity AT volkerrudolfjacobs thematernalbrainanorganwithperipartalplasticity AT thorstenfischer thematernalbrainanorganwithperipartalplasticity AT ludwigaigner thematernalbrainanorganwithperipartalplasticity AT katharinamariahillerer maternalbrainanorganwithperipartalplasticity AT volkerrudolfjacobs maternalbrainanorganwithperipartalplasticity AT thorstenfischer maternalbrainanorganwithperipartalplasticity AT ludwigaigner maternalbrainanorganwithperipartalplasticity |