Genetics of Keratoconus: Where Do We Stand?
Keratoconus is a progressive thinning and anterior protrusion of the cornea that results in steepening and distortion of the cornea, altered refractive powers, and reduced vision. Keratoconus has a complex multifactorial etiology, with environmental, behavioral, and multiple genetic components contr...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/641708 |
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| _version_ | 1832568109046693888 |
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| author | Khaled K. Abu-Amero Abdulrahman M. Al-Muammar Altaf A. Kondkar |
| author_facet | Khaled K. Abu-Amero Abdulrahman M. Al-Muammar Altaf A. Kondkar |
| author_sort | Khaled K. Abu-Amero |
| collection | DOAJ |
| description | Keratoconus is a progressive thinning and anterior protrusion of the cornea that results in steepening and distortion of the cornea, altered refractive powers, and reduced vision. Keratoconus has a complex multifactorial etiology, with environmental, behavioral, and multiple genetic components contributing to the disease pathophysiology. Using genome-wide and candidate gene approaches several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. The review focuses on current knowledge of these genetic risk factors associated with keratoconus. |
| format | Article |
| id | doaj-art-d72b96e8b56640cd8614b3e025a390c1 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-d72b96e8b56640cd8614b3e025a390c12025-02-03T00:59:46ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/641708641708Genetics of Keratoconus: Where Do We Stand?Khaled K. Abu-Amero0Abdulrahman M. Al-Muammar1Altaf A. Kondkar2Ophthalmic Genetics Laboratory, Department of Ophthalmology, College of Medicine, King Saud University, P.O. Box 245, Riyadh 11411, Saudi ArabiaOphthalmic Genetics Laboratory, Department of Ophthalmology, College of Medicine, King Saud University, P.O. Box 245, Riyadh 11411, Saudi ArabiaOphthalmic Genetics Laboratory, Department of Ophthalmology, College of Medicine, King Saud University, P.O. Box 245, Riyadh 11411, Saudi ArabiaKeratoconus is a progressive thinning and anterior protrusion of the cornea that results in steepening and distortion of the cornea, altered refractive powers, and reduced vision. Keratoconus has a complex multifactorial etiology, with environmental, behavioral, and multiple genetic components contributing to the disease pathophysiology. Using genome-wide and candidate gene approaches several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. The review focuses on current knowledge of these genetic risk factors associated with keratoconus.http://dx.doi.org/10.1155/2014/641708 |
| spellingShingle | Khaled K. Abu-Amero Abdulrahman M. Al-Muammar Altaf A. Kondkar Genetics of Keratoconus: Where Do We Stand? Journal of Ophthalmology |
| title | Genetics of Keratoconus: Where Do We Stand? |
| title_full | Genetics of Keratoconus: Where Do We Stand? |
| title_fullStr | Genetics of Keratoconus: Where Do We Stand? |
| title_full_unstemmed | Genetics of Keratoconus: Where Do We Stand? |
| title_short | Genetics of Keratoconus: Where Do We Stand? |
| title_sort | genetics of keratoconus where do we stand |
| url | http://dx.doi.org/10.1155/2014/641708 |
| work_keys_str_mv | AT khaledkabuamero geneticsofkeratoconuswheredowestand AT abdulrahmanmalmuammar geneticsofkeratoconuswheredowestand AT altafakondkar geneticsofkeratoconuswheredowestand |