Optimized D-α-tocopherol polyethylene glycol succinate/phospholipid self-assembled mixed micelles: A promising lipid-based nanoplatform for augmenting the antifungal activity of fluconazole

Optimized D-α-tocopherol polyethylene glycol succinate/phospholipid self-assembled mixed micelles: A promising lipid-based nanoplatform for augmenting the antifungal activity of fluconazole

Fluconazole (FLZ) is the most widely used antifungal agent for treating cutaneous candidiasis. Although oral FLZ has been proved to be effective, the incidence of side effects necessitates the development of an effective formulation that could surpass the pitfalls associated with systemic availabili...

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Main Authors: Badr-Eldin Shaimaa M., Aldawsari Hibah M., Fahmy Usama A., Ahmed Osama A. A., Alhakamy Nabil A., Elfaky Mahmoud A., Sirwi Alaa, Hawsawi Salman A., Alzahrani Ali H., Yaseen Abdulrahman Y., Qassim Mohannad, Kotta Sabna
Format: Article
Language:English
Published: Sciendo 2022-12-01
Series:Acta Pharmaceutica
Subjects:
fluconazole
fungal infections
candida albi-cans
self-assembled mixed micelles
d-α-tocopheryl polyethylene glycol 1000 succinate
phospholipids
Online Access:https://doi.org/10.2478/acph-2022-0028
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https://doi.org/10.2478/acph-2022-0028

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