Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite Sheet

This paper describes the processing and in vitro behavior of a poly(lactic acid) (PLA)-fiber/hydroxyapatite (HA) composite sheet consisting of a knitted PLA-fiber sheet and HA powder for bone tissue engineering. Type I collagen was used as a binding agent to combine the PLA fibers and the HA powder....

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Main Authors: Yasuhiro Tanimoto, Norihiro Nishiyama
Format: Article
Language:English
Published: Wiley 2009-01-01
Series:Advances in Materials Science and Engineering
Online Access:http://dx.doi.org/10.1155/2009/827241
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author Yasuhiro Tanimoto
Norihiro Nishiyama
author_facet Yasuhiro Tanimoto
Norihiro Nishiyama
author_sort Yasuhiro Tanimoto
collection DOAJ
description This paper describes the processing and in vitro behavior of a poly(lactic acid) (PLA)-fiber/hydroxyapatite (HA) composite sheet consisting of a knitted PLA-fiber sheet and HA powder for bone tissue engineering. Type I collagen was used as a binding agent to combine the PLA fibers and the HA powder. Precipitate formation in Hanks' balanced salt (HBS) solution was monitored to evaluate the in vitro apatite formation ability of the PLA-fiber/HA composite sheet. Precipitate formation was observed on the surface of the PLA-fiber/HA composite sheet after immersion in HBS solution for only 1 day, while no precipitate formation was observed on the PLA-fiber sheet without HA as a control. In conclusion, a PLA-fiber/HA composite sheet for use as a scaffold was successfully prepared. Within the limitations of this investigation, we confirmed that the PLA-fiber/HA composite sheet has a high apatite formation activity compared with the PLA-fiber sheet and represents a promising material for use as a scaffold.
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spelling doaj-art-d703411e31a84856a685336efab866822025-02-03T06:01:22ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422009-01-01200910.1155/2009/827241827241Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite SheetYasuhiro Tanimoto0Norihiro Nishiyama1Department of Dental Biomaterials, Nihon University School of Dentistry at Matsudo, 2-870-1 Sakaecho Nishi, Matsudo, Chiba 271-8587, JapanDepartment of Dental Biomaterials, Nihon University School of Dentistry at Matsudo, 2-870-1 Sakaecho Nishi, Matsudo, Chiba 271-8587, JapanThis paper describes the processing and in vitro behavior of a poly(lactic acid) (PLA)-fiber/hydroxyapatite (HA) composite sheet consisting of a knitted PLA-fiber sheet and HA powder for bone tissue engineering. Type I collagen was used as a binding agent to combine the PLA fibers and the HA powder. Precipitate formation in Hanks' balanced salt (HBS) solution was monitored to evaluate the in vitro apatite formation ability of the PLA-fiber/HA composite sheet. Precipitate formation was observed on the surface of the PLA-fiber/HA composite sheet after immersion in HBS solution for only 1 day, while no precipitate formation was observed on the PLA-fiber sheet without HA as a control. In conclusion, a PLA-fiber/HA composite sheet for use as a scaffold was successfully prepared. Within the limitations of this investigation, we confirmed that the PLA-fiber/HA composite sheet has a high apatite formation activity compared with the PLA-fiber sheet and represents a promising material for use as a scaffold.http://dx.doi.org/10.1155/2009/827241
spellingShingle Yasuhiro Tanimoto
Norihiro Nishiyama
Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite Sheet
Advances in Materials Science and Engineering
title Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite Sheet
title_full Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite Sheet
title_fullStr Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite Sheet
title_full_unstemmed Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite Sheet
title_short Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite Sheet
title_sort preparation and in vitro behavior of a poly lactic acid fiber hydroxyapatite composite sheet
url http://dx.doi.org/10.1155/2009/827241
work_keys_str_mv AT yasuhirotanimoto preparationandinvitrobehaviorofapolylacticacidfiberhydroxyapatitecompositesheet
AT norihironishiyama preparationandinvitrobehaviorofapolylacticacidfiberhydroxyapatitecompositesheet