Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment

Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment

Reactive astrogliosis and acidosis, common features of epileptogenic lesions, express a high level of astrocytic acid-sensing ion channel-1a (ASIC1a), a proton-gated cation channel and key mediator of responses to neuronal injury. This study investigates the role of astrocytic ASIC1a in cognitive im...

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Bibliographic Details
Main Authors: Wen Li, Huimin Zhou, Xiaona Li, Gengyao Hu, Dong Wei
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomolecules
Subjects:
ASIC1a
cognitive impairment
epilepsy
intracellular Ca<sup>2</sup>
glutamate glial neurotransmitter receptors
synaptic proteins
Online Access:https://www.mdpi.com/2218-273X/15/1/142
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