Microbiota-derived indole acetic acid extends lifespan through the AhR-Sirt2 pathway in Drosophila

Microbiota-derived indole acetic acid extends lifespan through the AhR-Sirt2 pathway in Drosophila

ABSTRACT Disruption of aryl hydrocarbon receptor (AhR) signaling and aberrant tryptophan metabolism have been shown to be highly associated with aging and age-related disorders. However, the underlying molecular mechanisms by which the AhR-mediated signaling pathway contributes to the aging process...

Full description

Saved in:
Bibliographic Details
Main Authors: Zheng Cao, Cui Zhang, Lijun Liu, Hehua Lei, Huabao Zhang, Yanmeng He, Xinzhi Li, Qingwei Xiang, Yu-Feng Wang, Limin Zhang, Gang Chen
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSystems
Subjects:
Aging
AhR
Sirt2
Drosophila
Online Access:https://journals.asm.org/doi/10.1128/msystems.01665-24
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items