Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus
Aims. T2DM often remains undiagnosed for many years because hyperglycemia develops gradually and may not produce any symptoms. As patients with T2DM are at increased risk of microvascular and macrovascular complications, the preclinical diagnosis of the state is the key point of the disease manageme...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2016/7497614 |
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| _version_ | 1832553641070821376 |
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| author | Pierina De Muro Antonio Junior Lepedda Gabriele Nieddu Michela Idini Hai Quy Tram Nguyen Omar Lobina Pietro Fresu Marilena Formato |
| author_facet | Pierina De Muro Antonio Junior Lepedda Gabriele Nieddu Michela Idini Hai Quy Tram Nguyen Omar Lobina Pietro Fresu Marilena Formato |
| author_sort | Pierina De Muro |
| collection | DOAJ |
| description | Aims. T2DM often remains undiagnosed for many years because hyperglycemia develops gradually and may not produce any symptoms. As patients with T2DM are at increased risk of microvascular and macrovascular complications, the preclinical diagnosis of the state is the key point of the disease management. Methods. We evaluated parameters such as GAGs/PGs, NAG, and NGAL in urine samples from 43 normoalbuminuric T2DM patients and 31 apparently healthy control subjects. Results. The total urinary GAG excretion showed no significant differences between patients and controls. The electrophoretic analysis evidenced the presence of UTI and its degradation products (LSC and SM-LSC), CS, and HS. We observed modifications of HS and total UTI (including UTI and its degradation products) relative contents in T2DM patients compared with controls whereas no differences in CS percentage were found. NGAL levels were significantly increased in T2DM patients and were positively correlated with both NAG (r=0.606, p<0.0001) and the presence of hypertension (r=0.352, p<0.05). Conclusions. These data suggest that the assessed molecules could represent useful markers to detect early renal impairment in patients with T2DM. |
| format | Article |
| id | doaj-art-d6dfdf1966c24b109aec4526b5b40199 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-d6dfdf1966c24b109aec4526b5b401992025-02-03T05:53:41ZengWileyBiochemistry Research International2090-22472090-22552016-01-01201610.1155/2016/74976147497614Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes MellitusPierina De Muro0Antonio Junior Lepedda1Gabriele Nieddu2Michela Idini3Hai Quy Tram Nguyen4Omar Lobina5Pietro Fresu6Marilena Formato7Department of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyDepartment of Diabetology and Metabolic Disease, AOU-Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, ItalyAims. T2DM often remains undiagnosed for many years because hyperglycemia develops gradually and may not produce any symptoms. As patients with T2DM are at increased risk of microvascular and macrovascular complications, the preclinical diagnosis of the state is the key point of the disease management. Methods. We evaluated parameters such as GAGs/PGs, NAG, and NGAL in urine samples from 43 normoalbuminuric T2DM patients and 31 apparently healthy control subjects. Results. The total urinary GAG excretion showed no significant differences between patients and controls. The electrophoretic analysis evidenced the presence of UTI and its degradation products (LSC and SM-LSC), CS, and HS. We observed modifications of HS and total UTI (including UTI and its degradation products) relative contents in T2DM patients compared with controls whereas no differences in CS percentage were found. NGAL levels were significantly increased in T2DM patients and were positively correlated with both NAG (r=0.606, p<0.0001) and the presence of hypertension (r=0.352, p<0.05). Conclusions. These data suggest that the assessed molecules could represent useful markers to detect early renal impairment in patients with T2DM.http://dx.doi.org/10.1155/2016/7497614 |
| spellingShingle | Pierina De Muro Antonio Junior Lepedda Gabriele Nieddu Michela Idini Hai Quy Tram Nguyen Omar Lobina Pietro Fresu Marilena Formato Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus Biochemistry Research International |
| title | Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus |
| title_full | Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus |
| title_short | Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus |
| title_sort | evaluation of early markers of nephropathy in patients with type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2016/7497614 |
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