Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocol

Introduction Exposure to gender-based violence (GBV) and violence against children (VAC) can result in substantial morbidity and mortality. Previous reviews of health outcomes associated with GBV and VAC have focused on limited definitions of exposure to violence (ie, intimate partner violence) and...

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Main Authors: Joht Singh Chandan, Emmanuela Gakidou, Jaidev Kaur Chandan, Nicholas Metheny, Mariam Khalil, Cory N Spencer, María Jose Baeza, Alexandra Debure, Molly Herbert, Teresa Jewell, Rachel Qian Hui Lim, Sonica Minhas
Format: Article
Language:English
Published: BMJ Publishing Group 2022-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/12/6/e061248.full
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author Joht Singh Chandan
Emmanuela Gakidou
Jaidev Kaur Chandan
Nicholas Metheny
Mariam Khalil
Cory N Spencer
María Jose Baeza
Alexandra Debure
Molly Herbert
Teresa Jewell
Rachel Qian Hui Lim
Sonica Minhas
author_facet Joht Singh Chandan
Emmanuela Gakidou
Jaidev Kaur Chandan
Nicholas Metheny
Mariam Khalil
Cory N Spencer
María Jose Baeza
Alexandra Debure
Molly Herbert
Teresa Jewell
Rachel Qian Hui Lim
Sonica Minhas
author_sort Joht Singh Chandan
collection DOAJ
description Introduction Exposure to gender-based violence (GBV) and violence against children (VAC) can result in substantial morbidity and mortality. Previous reviews of health outcomes associated with GBV and VAC have focused on limited definitions of exposure to violence (ie, intimate partner violence) and often investigate associations only with predefined health outcomes. In this protocol, we describe a systematic review and meta-analysis for a comprehensive assessment of the impact of violence exposure on health outcomes and health-related risk factors across the life-course.Methods and analysis Electronic databases (PubMed, Embase, CINAHL, PsycINFO, Global Index Medicus, Cochrane and Web of Science Core Collection) will be searched from 1 January 1970 to 30 September 2021 and searches updated to the current date prior to final preparation of results. Reviewers will first screen titles and abstracts, and eligible articles will then be full-text screened and accepted should they meet all inclusion criteria. Data will be extracted using a standardised form with fields to capture study characteristics and estimates of association between violence exposure and health outcomes. Individual study quality will be assessed via six risk of bias criteria. For exposure–outcome pairs with sufficient data, evidence will be synthesised via a meta-regression—Bayesian, regularised, trimmed model and confidence in the cumulative evidence assessed via the burden of proof risk function. Where possible, variations in associations by subgroup, that is, age, sex or gender, will be explored.Ethics and dissemination Formal ethical approval is not required. Findings from this review will be used to inform improved estimation of GBV and VAC within the Global Burden of Disease Study. The review has been undertaken in conjunction with the Lancet Commission on GBV and the Maltreatment of Young People with the aim of providing new data insights for a report on the global response to violence.PROSPERO registration number CRD42022299831.
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spelling doaj-art-d6d89a9c5fd044f08ae5356ceddafd422025-01-28T05:35:14ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2022-061248Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocolJoht Singh Chandan0Emmanuela Gakidou1Jaidev Kaur Chandan2Nicholas Metheny3Mariam Khalil4Cory N Spencer5María Jose Baeza6Alexandra Debure7Molly Herbert8Teresa Jewell9Rachel Qian Hui Lim10Sonica Minhas11Institute of Applied Health Research, University of Birmingham, Birmingham, UKInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USAWarwick Medical School, University of Warwick, Coventry, UKSchool of Nursing and Health Studies, University of Miami, Coral Gables, Florida, USAInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USAInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USASchool of Nursing and Health Studies, University of Miami, Coral Gables, Florida, USASchool of Nursing and Health Studies, University of Miami, Coral Gables, Florida, USAInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USAUniversity Libraries, University of Washington, Seattle, Washington, USABarts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UKBarts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UKIntroduction Exposure to gender-based violence (GBV) and violence against children (VAC) can result in substantial morbidity and mortality. Previous reviews of health outcomes associated with GBV and VAC have focused on limited definitions of exposure to violence (ie, intimate partner violence) and often investigate associations only with predefined health outcomes. In this protocol, we describe a systematic review and meta-analysis for a comprehensive assessment of the impact of violence exposure on health outcomes and health-related risk factors across the life-course.Methods and analysis Electronic databases (PubMed, Embase, CINAHL, PsycINFO, Global Index Medicus, Cochrane and Web of Science Core Collection) will be searched from 1 January 1970 to 30 September 2021 and searches updated to the current date prior to final preparation of results. Reviewers will first screen titles and abstracts, and eligible articles will then be full-text screened and accepted should they meet all inclusion criteria. Data will be extracted using a standardised form with fields to capture study characteristics and estimates of association between violence exposure and health outcomes. Individual study quality will be assessed via six risk of bias criteria. For exposure–outcome pairs with sufficient data, evidence will be synthesised via a meta-regression—Bayesian, regularised, trimmed model and confidence in the cumulative evidence assessed via the burden of proof risk function. Where possible, variations in associations by subgroup, that is, age, sex or gender, will be explored.Ethics and dissemination Formal ethical approval is not required. Findings from this review will be used to inform improved estimation of GBV and VAC within the Global Burden of Disease Study. The review has been undertaken in conjunction with the Lancet Commission on GBV and the Maltreatment of Young People with the aim of providing new data insights for a report on the global response to violence.PROSPERO registration number CRD42022299831.https://bmjopen.bmj.com/content/12/6/e061248.full
spellingShingle Joht Singh Chandan
Emmanuela Gakidou
Jaidev Kaur Chandan
Nicholas Metheny
Mariam Khalil
Cory N Spencer
María Jose Baeza
Alexandra Debure
Molly Herbert
Teresa Jewell
Rachel Qian Hui Lim
Sonica Minhas
Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocol
BMJ Open
title Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocol
title_full Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocol
title_fullStr Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocol
title_full_unstemmed Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocol
title_short Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocol
title_sort estimating the global health impact of gender based violence and violence against children a systematic review and meta analysis protocol
url https://bmjopen.bmj.com/content/12/6/e061248.full
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