Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment
Abstract Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding the complexities of tumor development and mutation is the need of the hour for the advancement of ta...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Nano |
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| Online Access: | https://doi.org/10.1186/s11671-024-04163-w |
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| author | Amy Sarah Benjamin Sunita Nayak |
| author_facet | Amy Sarah Benjamin Sunita Nayak |
| author_sort | Amy Sarah Benjamin |
| collection | DOAJ |
| description | Abstract Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding the complexities of tumor development and mutation is the need of the hour for the advancement of targeted therapies in cancer care. A significant innovation in this area is the use of nanotechnology, specifically nanoparticles, to tackle various challenges in cancer treatment. Iron oxide nanoparticles stand out in both therapeutic and diagnostic applications, offering a versatile platform for targeted drug delivery, hyperthermia, magneto-thermal therapy, and combinational therapy using modulation of ferroptosis pathways. These nanoparticles are easy to synthesize, non-toxic, biocompatible, and display enhanced circulation time within the system. They can also be easily conjugated to anti-cancer drugs, targeting agents, or genetic vectors that respond to specific stimuli or pH changes. The surface functionalization of these nanoparticles using bioactive molecules unveils a promising and effective nanoparticle system for assisting osteosarcoma therapy. This review will summarize the current conventional therapies for osteosarcoma and their disadvantages, the synthesis and modification of iron oxide nanoparticles documented in the literature, cellular targeting and uptake mechanism, with focus on their functionalization using natural biomaterials and application strategies towards management of osteosarcoma. The review also compiles the translational challenges and future prospects that must be addressed for clinical advancements of iron oxide based osteosarcoma treatment in the future. Graphical abstract |
| format | Article |
| id | doaj-art-d6d6b809127141f4b81cecedeb7076f9 |
| institution | Kabale University |
| issn | 2731-9229 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Nano |
| spelling | doaj-art-d6d6b809127141f4b81cecedeb7076f92025-02-02T12:37:53ZengSpringerDiscover Nano2731-92292025-01-0120112210.1186/s11671-024-04163-wIron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatmentAmy Sarah Benjamin0Sunita Nayak1School of Advanced Sciences, Vellore Institute of TechnologySchool of Biosciences and Technology, Vellore Institute of TechnologyAbstract Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding the complexities of tumor development and mutation is the need of the hour for the advancement of targeted therapies in cancer care. A significant innovation in this area is the use of nanotechnology, specifically nanoparticles, to tackle various challenges in cancer treatment. Iron oxide nanoparticles stand out in both therapeutic and diagnostic applications, offering a versatile platform for targeted drug delivery, hyperthermia, magneto-thermal therapy, and combinational therapy using modulation of ferroptosis pathways. These nanoparticles are easy to synthesize, non-toxic, biocompatible, and display enhanced circulation time within the system. They can also be easily conjugated to anti-cancer drugs, targeting agents, or genetic vectors that respond to specific stimuli or pH changes. The surface functionalization of these nanoparticles using bioactive molecules unveils a promising and effective nanoparticle system for assisting osteosarcoma therapy. This review will summarize the current conventional therapies for osteosarcoma and their disadvantages, the synthesis and modification of iron oxide nanoparticles documented in the literature, cellular targeting and uptake mechanism, with focus on their functionalization using natural biomaterials and application strategies towards management of osteosarcoma. The review also compiles the translational challenges and future prospects that must be addressed for clinical advancements of iron oxide based osteosarcoma treatment in the future. Graphical abstracthttps://doi.org/10.1186/s11671-024-04163-wNanotechnologyIron oxide nanoparticlesMagnetic propertiesBio-active polymersOsteosarcomaCancer nanomedicine |
| spellingShingle | Amy Sarah Benjamin Sunita Nayak Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment Discover Nano Nanotechnology Iron oxide nanoparticles Magnetic properties Bio-active polymers Osteosarcoma Cancer nanomedicine |
| title | Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment |
| title_full | Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment |
| title_fullStr | Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment |
| title_full_unstemmed | Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment |
| title_short | Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment |
| title_sort | iron oxide nanoparticles coated with bioactive materials a viable theragnostic strategy to improve osteosarcoma treatment |
| topic | Nanotechnology Iron oxide nanoparticles Magnetic properties Bio-active polymers Osteosarcoma Cancer nanomedicine |
| url | https://doi.org/10.1186/s11671-024-04163-w |
| work_keys_str_mv | AT amysarahbenjamin ironoxidenanoparticlescoatedwithbioactivematerialsaviabletheragnosticstrategytoimproveosteosarcomatreatment AT sunitanayak ironoxidenanoparticlescoatedwithbioactivematerialsaviabletheragnosticstrategytoimproveosteosarcomatreatment |