IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease
Studies have reported that immunoglobulin G (IgG) "deposited" in the basement membrane of renal tubules is associated with tubulointerstitial damage in patients with diabetic kidney disease (DKD). Our previous study found that renal tubular epithelial cells (RTECs) can express and secrete...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2458764 |
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| author | Xinyao Wang Zhenling Deng Yue Wang |
| author_facet | Xinyao Wang Zhenling Deng Yue Wang |
| author_sort | Xinyao Wang |
| collection | DOAJ |
| description | Studies have reported that immunoglobulin G (IgG) "deposited" in the basement membrane of renal tubules is associated with tubulointerstitial damage in patients with diabetic kidney disease (DKD). Our previous study found that renal tubular epithelial cells (RTECs) can express and secrete IgG (RTEC-IgG) which may be associated with fibrosis. The present study aimed to explore the role of RTEC-IgG in renal tubulointerstitial fibrosis (TIF) in DKD. The results showed that RTEC-IgG expression was up-regulated in the renal tubulointerstitium of DKD patients and was associated with worse kidney function, more severe anemia, and higher interstitial fibrosis and tubular atrophy (IFTA) scores, and positively correlated with tubular epithelial mesenchymal transition (EMT) and TIF. IgG expression was also enhanced in the renal tubulointerstitium of DKD mice, which was positively correlated with TIF. High glucose induced an over expression of IgG in human renal tubular epithelial cells, and knockdown of IgG with siRNA relieved the expression of α-smooth muscle actin (SMA), collagen IV, fibronectin, and transforming growth factor (TGF)-β1 under high glucose conditions. In conclusion, our study suggests that RTEC-IgG is involved in the development of DKD by promoting EMT and interstitial fibrosis via TGF-β1. |
| format | Article |
| id | doaj-art-d6ca92dda377426cbacb4c7db84de6a1 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-d6ca92dda377426cbacb4c7db84de6a12025-02-04T06:07:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2458764IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney diseaseXinyao Wang0Zhenling Deng1Yue Wang2Department of Nephrology, Peking University Third Hospital, Beijing, ChinaDepartment of Nephrology, Peking University Third Hospital, Beijing, ChinaDepartment of Nephrology, Peking University Third Hospital, Beijing, ChinaStudies have reported that immunoglobulin G (IgG) "deposited" in the basement membrane of renal tubules is associated with tubulointerstitial damage in patients with diabetic kidney disease (DKD). Our previous study found that renal tubular epithelial cells (RTECs) can express and secrete IgG (RTEC-IgG) which may be associated with fibrosis. The present study aimed to explore the role of RTEC-IgG in renal tubulointerstitial fibrosis (TIF) in DKD. The results showed that RTEC-IgG expression was up-regulated in the renal tubulointerstitium of DKD patients and was associated with worse kidney function, more severe anemia, and higher interstitial fibrosis and tubular atrophy (IFTA) scores, and positively correlated with tubular epithelial mesenchymal transition (EMT) and TIF. IgG expression was also enhanced in the renal tubulointerstitium of DKD mice, which was positively correlated with TIF. High glucose induced an over expression of IgG in human renal tubular epithelial cells, and knockdown of IgG with siRNA relieved the expression of α-smooth muscle actin (SMA), collagen IV, fibronectin, and transforming growth factor (TGF)-β1 under high glucose conditions. In conclusion, our study suggests that RTEC-IgG is involved in the development of DKD by promoting EMT and interstitial fibrosis via TGF-β1.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2458764Diabetic kidney diseaseepithelial mesenchymal transitionimmunoglobulin Grenal tubular epithelial cellrenal tubulointerstitial fibrosis |
| spellingShingle | Xinyao Wang Zhenling Deng Yue Wang IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease Renal Failure Diabetic kidney disease epithelial mesenchymal transition immunoglobulin G renal tubular epithelial cell renal tubulointerstitial fibrosis |
| title | IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease |
| title_full | IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease |
| title_fullStr | IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease |
| title_full_unstemmed | IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease |
| title_short | IgG expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease |
| title_sort | igg expressed by renal tubular epithelial cells in epithelial mesenchymal transformation and interstitial fibrosis in diabetic kidney disease |
| topic | Diabetic kidney disease epithelial mesenchymal transition immunoglobulin G renal tubular epithelial cell renal tubulointerstitial fibrosis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2458764 |
| work_keys_str_mv | AT xinyaowang iggexpressedbyrenaltubularepithelialcellsinepithelialmesenchymaltransformationandinterstitialfibrosisindiabetickidneydisease AT zhenlingdeng iggexpressedbyrenaltubularepithelialcellsinepithelialmesenchymaltransformationandinterstitialfibrosisindiabetickidneydisease AT yuewang iggexpressedbyrenaltubularepithelialcellsinepithelialmesenchymaltransformationandinterstitialfibrosisindiabetickidneydisease |