A Feasibility Study for Microwave Breast Cancer Detection Using Contrast-Agent-Loaded Bacterial Microbots
We propose a new approach to microwave breast tumor sensing and diagnosis based on the use of biocompatible flagellated magnetotactic bacteria (MTB) adapted to operate in human microvasculature. It has been verified experimentally by Martel et al. that externally generated magnetic gradients could b...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Antennas and Propagation |
| Online Access: | http://dx.doi.org/10.1155/2013/309703 |
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| author | Yifan Chen Panagiotis Kosmas Sylvain Martel |
| author_facet | Yifan Chen Panagiotis Kosmas Sylvain Martel |
| author_sort | Yifan Chen |
| collection | DOAJ |
| description | We propose a new approach to microwave breast tumor sensing and diagnosis based on the use of biocompatible flagellated magnetotactic bacteria (MTB) adapted to operate in human microvasculature. It has been verified experimentally by Martel et al. that externally generated magnetic gradients could be applied to guide the MTB along preplanned routes inside the human body, and a nanoload could be attached to these bacterial microbots. Motivated by these useful properties, we suggest loading a nanoscale microwave contrast agent such as carbon nanotubes (CNTs) or ferroelectric nanoparticles (FNPs) onto the MTB in order to modify the dielectric properties of tissues near the agent-loaded bacteria. Subsequently, we propose a novel differential microwave imaging (DMI) technique to track simultaneously multiple swarms of MTB microbots injected into the breast. We also present innovative strategies to detect and localize a breast tissue malignancy and estimate its size via this DMI-trackable bacterial microrobotic system. Finally, we use an anatomically realistic numerical breast phantom as a platform to demonstrate the feasibility of this tumor diagnostic method. |
| format | Article |
| id | doaj-art-d6b3abf776cf49beba68a73d84398e38 |
| institution | Kabale University |
| issn | 1687-5869 1687-5877 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Antennas and Propagation |
| spelling | doaj-art-d6b3abf776cf49beba68a73d84398e382025-02-03T01:27:51ZengWileyInternational Journal of Antennas and Propagation1687-58691687-58772013-01-01201310.1155/2013/309703309703A Feasibility Study for Microwave Breast Cancer Detection Using Contrast-Agent-Loaded Bacterial MicrobotsYifan Chen0Panagiotis Kosmas1Sylvain Martel2Department of Electrical and Electronic Engineering, South University of Science and Technology of China, Shenzhen 518055, ChinaSchool of Natural and Mathematical Sciences, King’s College London, London WC2R 2LS, UKDepartment of Computer Engineering, Ecole Polytechnique de Montreal, Montreal, H3T 1J4, CanadaWe propose a new approach to microwave breast tumor sensing and diagnosis based on the use of biocompatible flagellated magnetotactic bacteria (MTB) adapted to operate in human microvasculature. It has been verified experimentally by Martel et al. that externally generated magnetic gradients could be applied to guide the MTB along preplanned routes inside the human body, and a nanoload could be attached to these bacterial microbots. Motivated by these useful properties, we suggest loading a nanoscale microwave contrast agent such as carbon nanotubes (CNTs) or ferroelectric nanoparticles (FNPs) onto the MTB in order to modify the dielectric properties of tissues near the agent-loaded bacteria. Subsequently, we propose a novel differential microwave imaging (DMI) technique to track simultaneously multiple swarms of MTB microbots injected into the breast. We also present innovative strategies to detect and localize a breast tissue malignancy and estimate its size via this DMI-trackable bacterial microrobotic system. Finally, we use an anatomically realistic numerical breast phantom as a platform to demonstrate the feasibility of this tumor diagnostic method.http://dx.doi.org/10.1155/2013/309703 |
| spellingShingle | Yifan Chen Panagiotis Kosmas Sylvain Martel A Feasibility Study for Microwave Breast Cancer Detection Using Contrast-Agent-Loaded Bacterial Microbots International Journal of Antennas and Propagation |
| title | A Feasibility Study for Microwave Breast Cancer Detection Using Contrast-Agent-Loaded Bacterial Microbots |
| title_full | A Feasibility Study for Microwave Breast Cancer Detection Using Contrast-Agent-Loaded Bacterial Microbots |
| title_fullStr | A Feasibility Study for Microwave Breast Cancer Detection Using Contrast-Agent-Loaded Bacterial Microbots |
| title_full_unstemmed | A Feasibility Study for Microwave Breast Cancer Detection Using Contrast-Agent-Loaded Bacterial Microbots |
| title_short | A Feasibility Study for Microwave Breast Cancer Detection Using Contrast-Agent-Loaded Bacterial Microbots |
| title_sort | feasibility study for microwave breast cancer detection using contrast agent loaded bacterial microbots |
| url | http://dx.doi.org/10.1155/2013/309703 |
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