Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming

Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming

Research indicates that abnormal gut microbiota metabolism is linked to colorectal cancer (CRC) progression, but the role of microbiota-related tryptophan metabolism disruption remains unclear. Using metagenomic sequencing and targeted Trp metabolomics, our research identified that CRC patients had...

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Bibliographic Details
Main Authors: Shizhen Zhou, Kai Wang, Jiandong Huang, Zhen Xu, Qinggang Yuan, Lixiang Liu, Zhifeng Wang, Ji Miao, Hao Wang, Tingting Wang, Wenxian Guan, Chao Ding
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Indole-3-lactic acid
HK2
P-STAT3
glycolysis
colorectal cancer
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2508949
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