Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer
Over the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms. ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, in...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2017/4723193 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559378011521024 |
|---|---|
| author | Marco Ragusa Cristina Barbagallo Duilia Brex Angela Caponnetto Matilde Cirnigliaro Rosalia Battaglia Davide Barbagallo Cinzia Di Pietro Michele Purrello |
| author_facet | Marco Ragusa Cristina Barbagallo Duilia Brex Angela Caponnetto Matilde Cirnigliaro Rosalia Battaglia Davide Barbagallo Cinzia Di Pietro Michele Purrello |
| author_sort | Marco Ragusa |
| collection | DOAJ |
| description | Over the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms. ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, including cancer. To date, most research efforts have been mainly focused on how ncRNAs could modulate the expression of protein-coding genes in pathological phenotypes. However, recent evidence has shown the existence of an unexpected interplay among ncRNAs that strongly influences cancer development and progression. ncRNAs can interact with and regulate each other through various molecular mechanisms generating a complex network including different species of RNAs (e.g., mRNAs, miRNAs, lncRNAs, and circRNAs). Such a hidden network of RNA-RNA competitive interactions pervades and modulates the physiological functioning of canonical protein-coding pathways involved in proliferation, differentiation, and metastasis in cancer. Moreover, the pivotal role of ncRNAs as keystones of network structural integrity makes them very attractive and promising targets for innovative RNA-based therapeutics. In this review we will discuss: (1) the current knowledge on complex crosstalk among ncRNAs, with a special focus on cancer; and (2) the main issues and criticisms concerning ncRNAs targeting in therapeutics. |
| format | Article |
| id | doaj-art-d6aa9c9a85634267a67ab41831ec708e |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-d6aa9c9a85634267a67ab41831ec708e2025-02-03T01:30:13ZengWileyInternational Journal of Genomics2314-436X2314-43782017-01-01201710.1155/2017/47231934723193Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in CancerMarco Ragusa0Cristina Barbagallo1Duilia Brex2Angela Caponnetto3Matilde Cirnigliaro4Rosalia Battaglia5Davide Barbagallo6Cinzia Di Pietro7Michele Purrello8BioMolecular, Genome and Complex Systems BioMedicine Unit (BMGS Unit), Section of Biology and Genetics G Sichel, Department of BioMedical Sciences and Biotechnology, University of Catania, Catania, ItalyBioMolecular, Genome and Complex Systems BioMedicine Unit (BMGS Unit), Section of Biology and Genetics G Sichel, Department of BioMedical Sciences and Biotechnology, University of Catania, Catania, ItalyBioMolecular, Genome and Complex Systems BioMedicine Unit (BMGS Unit), Section of Biology and Genetics G Sichel, Department of BioMedical Sciences and Biotechnology, University of Catania, Catania, ItalyBioMolecular, Genome and Complex Systems BioMedicine Unit (BMGS Unit), Section of Biology and Genetics G Sichel, Department of BioMedical Sciences and Biotechnology, University of Catania, Catania, ItalyBioMolecular, Genome and Complex Systems BioMedicine Unit (BMGS Unit), Section of Biology and Genetics G Sichel, Department of BioMedical Sciences and Biotechnology, University of Catania, Catania, ItalyBioMolecular, Genome and Complex Systems BioMedicine Unit (BMGS Unit), Section of Biology and Genetics G Sichel, Department of BioMedical Sciences and Biotechnology, University of Catania, Catania, ItalyBioMolecular, Genome and Complex Systems BioMedicine Unit (BMGS Unit), Section of Biology and Genetics G Sichel, Department of BioMedical Sciences and Biotechnology, University of Catania, Catania, ItalyBioMolecular, Genome and Complex Systems BioMedicine Unit (BMGS Unit), Section of Biology and Genetics G Sichel, Department of BioMedical Sciences and Biotechnology, University of Catania, Catania, ItalyBioMolecular, Genome and Complex Systems BioMedicine Unit (BMGS Unit), Section of Biology and Genetics G Sichel, Department of BioMedical Sciences and Biotechnology, University of Catania, Catania, ItalyOver the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms. ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, including cancer. To date, most research efforts have been mainly focused on how ncRNAs could modulate the expression of protein-coding genes in pathological phenotypes. However, recent evidence has shown the existence of an unexpected interplay among ncRNAs that strongly influences cancer development and progression. ncRNAs can interact with and regulate each other through various molecular mechanisms generating a complex network including different species of RNAs (e.g., mRNAs, miRNAs, lncRNAs, and circRNAs). Such a hidden network of RNA-RNA competitive interactions pervades and modulates the physiological functioning of canonical protein-coding pathways involved in proliferation, differentiation, and metastasis in cancer. Moreover, the pivotal role of ncRNAs as keystones of network structural integrity makes them very attractive and promising targets for innovative RNA-based therapeutics. In this review we will discuss: (1) the current knowledge on complex crosstalk among ncRNAs, with a special focus on cancer; and (2) the main issues and criticisms concerning ncRNAs targeting in therapeutics.http://dx.doi.org/10.1155/2017/4723193 |
| spellingShingle | Marco Ragusa Cristina Barbagallo Duilia Brex Angela Caponnetto Matilde Cirnigliaro Rosalia Battaglia Davide Barbagallo Cinzia Di Pietro Michele Purrello Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer International Journal of Genomics |
| title | Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer |
| title_full | Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer |
| title_fullStr | Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer |
| title_full_unstemmed | Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer |
| title_short | Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer |
| title_sort | molecular crosstalking among noncoding rnas a new network layer of genome regulation in cancer |
| url | http://dx.doi.org/10.1155/2017/4723193 |
| work_keys_str_mv | AT marcoragusa molecularcrosstalkingamongnoncodingrnasanewnetworklayerofgenomeregulationincancer AT cristinabarbagallo molecularcrosstalkingamongnoncodingrnasanewnetworklayerofgenomeregulationincancer AT duiliabrex molecularcrosstalkingamongnoncodingrnasanewnetworklayerofgenomeregulationincancer AT angelacaponnetto molecularcrosstalkingamongnoncodingrnasanewnetworklayerofgenomeregulationincancer AT matildecirnigliaro molecularcrosstalkingamongnoncodingrnasanewnetworklayerofgenomeregulationincancer AT rosaliabattaglia molecularcrosstalkingamongnoncodingrnasanewnetworklayerofgenomeregulationincancer AT davidebarbagallo molecularcrosstalkingamongnoncodingrnasanewnetworklayerofgenomeregulationincancer AT cinziadipietro molecularcrosstalkingamongnoncodingrnasanewnetworklayerofgenomeregulationincancer AT michelepurrello molecularcrosstalkingamongnoncodingrnasanewnetworklayerofgenomeregulationincancer |