Models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission
Hantavirus, a zoonotic disease carried by wild rodents, is spread among rodents via direct contact and indirectly via infected rodent excreta in the soil. Spillover to humans is primarily via the indirect route through inhalation of aerosolized viral particles. Rodent-hantavirus models that include...
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| Language: | English |
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AIMS Press
2009-12-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2010.7.195 |
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| author | Curtis L. Wesley Linda J. S. Allen Michel Langlais |
| author_facet | Curtis L. Wesley Linda J. S. Allen Michel Langlais |
| author_sort | Curtis L. Wesley |
| collection | DOAJ |
| description | Hantavirus, a zoonotic disease carried by wild rodents, is spread among rodents via direct contact and indirectly via infected rodent excreta in the soil. Spillover to humans is primarily via the indirect route through inhalation of aerosolized viral particles. Rodent-hantavirus models that include direct and indirect transmission and periodically varying demographic and epidemiological parameters are studied in this investigation. Two models are analyzed, a nonautonomous system of differential equations with time-periodic coefficients and an autonomous system, where the coefficients are taken to be the time-average. In the nonautonomous system, births, deaths, transmission rates and viral decay rates are assumed to be periodic. For both models, the basic reproduction numbers are calculated. The models are applied to two rodent populations, reservoirs for a New World and for an Old World hantavirus. The numerical examples show that periodically varying demographic and epidemiological parameters may substantially increase the basic reproduction number. Also, large variations in the viral decay rate in the environment coupled with an outbreak in rodent populations may lead to spillover infection in humans. |
| format | Article |
| id | doaj-art-d6a8ab29f2894e71a61221685352472c |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2009-12-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-d6a8ab29f2894e71a61221685352472c2025-01-24T02:00:16ZengAIMS PressMathematical Biosciences and Engineering1551-00182009-12-017119521110.3934/mbe.2010.7.195Models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmissionCurtis L. Wesley0Linda J. S. Allen1Michel Langlais2Louisiana State University in Shreveport, Department of Mathematics, Shreveport, LA 71115Louisiana State University in Shreveport, Department of Mathematics, Shreveport, LA 71115Louisiana State University in Shreveport, Department of Mathematics, Shreveport, LA 71115Hantavirus, a zoonotic disease carried by wild rodents, is spread among rodents via direct contact and indirectly via infected rodent excreta in the soil. Spillover to humans is primarily via the indirect route through inhalation of aerosolized viral particles. Rodent-hantavirus models that include direct and indirect transmission and periodically varying demographic and epidemiological parameters are studied in this investigation. Two models are analyzed, a nonautonomous system of differential equations with time-periodic coefficients and an autonomous system, where the coefficients are taken to be the time-average. In the nonautonomous system, births, deaths, transmission rates and viral decay rates are assumed to be periodic. For both models, the basic reproduction numbers are calculated. The models are applied to two rodent populations, reservoirs for a New World and for an Old World hantavirus. The numerical examples show that periodically varying demographic and epidemiological parameters may substantially increase the basic reproduction number. Also, large variations in the viral decay rate in the environment coupled with an outbreak in rodent populations may lead to spillover infection in humans.https://www.aimspress.com/article/doi/10.3934/mbe.2010.7.195periodic solutions.nonautonomoushantavirusbasic reproduction number |
| spellingShingle | Curtis L. Wesley Linda J. S. Allen Michel Langlais Models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission Mathematical Biosciences and Engineering periodic solutions. nonautonomous hantavirus basic reproduction number |
| title | Models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission |
| title_full | Models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission |
| title_fullStr | Models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission |
| title_full_unstemmed | Models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission |
| title_short | Models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission |
| title_sort | models for the spread and persistence of hantavirus infection in rodents with direct and indirect transmission |
| topic | periodic solutions. nonautonomous hantavirus basic reproduction number |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2010.7.195 |
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