Does Sex Matter in Obesity-Induced Periodontal Inflammation in the SS<sup>LepR</sup> Mutant Rats?
<b>Introduction:</b> The incidence of obesity has dramatically increased worldwide. Obesity has been shown to exacerbate the progression of periodontal disease. Studies suggest a sex difference in periodontitis, whereby males are more sensitive to periodontal inflammation compared to fem...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Dentistry Journal |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6767/13/1/14 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <b>Introduction:</b> The incidence of obesity has dramatically increased worldwide. Obesity has been shown to exacerbate the progression of periodontal disease. Studies suggest a sex difference in periodontitis, whereby males are more sensitive to periodontal inflammation compared to females. <b>Aim:</b> In the current study, it was hypothesized that obesity drives periodontal inflammation and bone loss in both sexes. <b>Methodology:</b> Utilizing leptin receptor mutant (SS<sup>LepR</sup> mutant) rats as a genetic model of obesity, 11–12-week-old male and female lean Dahl salt-sensitive (SS) rats and obese SS<sup>LepR</sup> mutant rats were used to investigate sex differences in obesity-induced periodontal inflammation. <b>Results:</b> Body weight, insulin, hemoglobin A1c and cholesterol levels were significantly elevated in the obese SS<sup>LepR</sup> mutant strain vs. the lean SS strain within the same sex. Sex differences in body weight and plasma hemoglobin A1c were only observed in obese SS<sup>LepR</sup> mutant rats, with males having significantly greater body weight and hemoglobin A1c vs. females. Plasma thiobarbituric acid reactive substances (TBARs) and monocyte chemoattractant protein-1 (MCP-1), markers of systemic oxidative stress and inflammation, respectively, were significantly elevated in obese SS<sup>LepR</sup> mutant rats vs. lean SS rats, with no sex differences in these parameters in either rat strains. Although micro-CT analyses of the maxillary first molar alveolar bone from obese SS<sup>LepR</sup> mutant rats revealed no evidence of bone loss and/or sex differences, immuno-histochemical analysis revealed significant elevations in periodontal IL-6 and decreases in IL-10 in obese SS<sup>LepR</sup> mutant rats vs. lean SS rats, with no apparent sex differences in these parameters. <b>Conclusions:</b> Obesity increases systemic and periodontal inflammation, without evidence of bone loss or apparent sex differences in SS<sup>LepR</sup> mutant rats. |
|---|---|
| ISSN: | 2304-6767 |