Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells

Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells

Abstract Lysine-specific histone demethylase 1 (LSD1) is a histone demethylase that plays a critical role in epigenetic regulation by removing the methyl group from mono- and di-methylated lysine 4 on histone H3 (H3K4me1/2), acting as a repressor of gene expression. Recently, catalytically independe...

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Main Authors: Sandhya Malla, Carlos Martinez-Gamero, Kanchan Kumari, Cyrinne Achour, Georgios Mermelekas, David Martinez-Delgado, Alba Coego, Diana Guallar, Angel-Carlos Roman, Francesca Aguilo
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-78920-3
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