Questioning the Extreme Neurovirulence of Monkey B Virus (Macacine alphaherpesvirus 1)
Monkey B virus (Macacine alphaherpesvirus 1; BV) occurs naturally in macaques of the genus Macaca, which includes rhesus and long-tailed (cynomolgus) monkeys that are widely used in biomedical research. BV is closely related to the human herpes simplex viruses (HSV), and BV infections in its natural...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2018/5248420 |
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| author | R. Eberle L. Jones-Engel |
| author_facet | R. Eberle L. Jones-Engel |
| author_sort | R. Eberle |
| collection | DOAJ |
| description | Monkey B virus (Macacine alphaherpesvirus 1; BV) occurs naturally in macaques of the genus Macaca, which includes rhesus and long-tailed (cynomolgus) monkeys that are widely used in biomedical research. BV is closely related to the human herpes simplex viruses (HSV), and BV infections in its natural macaque host are quite similar to HSV infections in humans. Zoonotic BV is extremely rare, having been diagnosed in only a handful of North American facilities with the last documented case occurring in 1998. However, BV is notorious for its neurovirulence since zoonotic infections are serious, usually involving the central nervous system, and are frequently fatal. Little is known about factors underlying the extreme neurovirulence of BV in humans. Here we review what is actually known about the molecular biology of BV and viral factors affecting its neurovirulence. Based on what is known about related herpesviruses, areas for future research that may elucidate mechanisms underlying the neurovirulence of this intriguing virus are also reviewed. |
| format | Article |
| id | doaj-art-d69b7aeeafe140419a0a554e57126e30 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-d69b7aeeafe140419a0a554e57126e302025-02-03T01:06:21ZengWileyAdvances in Virology1687-86391687-86472018-01-01201810.1155/2018/52484205248420Questioning the Extreme Neurovirulence of Monkey B Virus (Macacine alphaherpesvirus 1)R. Eberle0L. Jones-Engel1Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USADepartment of Anthropology and Center for Studies in Ecology and Demography, University of Washington, Seattle, WA 98195, USAMonkey B virus (Macacine alphaherpesvirus 1; BV) occurs naturally in macaques of the genus Macaca, which includes rhesus and long-tailed (cynomolgus) monkeys that are widely used in biomedical research. BV is closely related to the human herpes simplex viruses (HSV), and BV infections in its natural macaque host are quite similar to HSV infections in humans. Zoonotic BV is extremely rare, having been diagnosed in only a handful of North American facilities with the last documented case occurring in 1998. However, BV is notorious for its neurovirulence since zoonotic infections are serious, usually involving the central nervous system, and are frequently fatal. Little is known about factors underlying the extreme neurovirulence of BV in humans. Here we review what is actually known about the molecular biology of BV and viral factors affecting its neurovirulence. Based on what is known about related herpesviruses, areas for future research that may elucidate mechanisms underlying the neurovirulence of this intriguing virus are also reviewed.http://dx.doi.org/10.1155/2018/5248420 |
| spellingShingle | R. Eberle L. Jones-Engel Questioning the Extreme Neurovirulence of Monkey B Virus (Macacine alphaherpesvirus 1) Advances in Virology |
| title | Questioning the Extreme Neurovirulence of Monkey B Virus (Macacine alphaherpesvirus 1) |
| title_full | Questioning the Extreme Neurovirulence of Monkey B Virus (Macacine alphaherpesvirus 1) |
| title_fullStr | Questioning the Extreme Neurovirulence of Monkey B Virus (Macacine alphaherpesvirus 1) |
| title_full_unstemmed | Questioning the Extreme Neurovirulence of Monkey B Virus (Macacine alphaherpesvirus 1) |
| title_short | Questioning the Extreme Neurovirulence of Monkey B Virus (Macacine alphaherpesvirus 1) |
| title_sort | questioning the extreme neurovirulence of monkey b virus macacine alphaherpesvirus 1 |
| url | http://dx.doi.org/10.1155/2018/5248420 |
| work_keys_str_mv | AT reberle questioningtheextremeneurovirulenceofmonkeybvirusmacacinealphaherpesvirus1 AT ljonesengel questioningtheextremeneurovirulenceofmonkeybvirusmacacinealphaherpesvirus1 |