Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase
Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (MΦ) which could explain the perpetuation of inflammation associated...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Mediators of Inflammation |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09629359890758 |
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| _version_ | 1832564150511861760 |
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| author | Monique P. Gelderman Rodney Stuart David Vigerust Steven Fuhrmann Doris L. Lefkowitz Robert C. Allen Stanley S. Lefkowitz Susan Graham |
| author_facet | Monique P. Gelderman Rodney Stuart David Vigerust Steven Fuhrmann Doris L. Lefkowitz Robert C. Allen Stanley S. Lefkowitz Susan Graham |
| author_sort | Monique P. Gelderman |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (MΦ) which could explain the perpetuation of inflammation associated with RA. A monoarticular arthritis was induced in female Lewis rats by injection of streptococcal cell wall extracts (PG-APS). After swelling and erythema subsided, joints were re-injected with one of the following: porcine MPO or partially inactivated MPO (iMPO). Injection with either MPO or iMPO induced a 'flare' of experimental RA. Blocking the MΦ-mannose receptor by mannans, ablated exacerbation of disease. These results indicate that MPO or iMPO can play a pivotal role in the perpetuation but not initiation of this RA model. |
| format | Article |
| id | doaj-art-d69301bb9b8b4b02b7e0eb493436dc7e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d69301bb9b8b4b02b7e0eb493436dc7e2025-02-03T01:11:48ZengWileyMediators of Inflammation0962-93511466-18611998-01-017638138910.1080/09629359890758Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidaseMonique P. Gelderman0Rodney Stuart1David Vigerust2Steven Fuhrmann3Doris L. Lefkowitz4Robert C. Allen5Stanley S. Lefkowitz6Susan Graham7National Institutes of Health, Bethesda, MD 20931, USATexas Tech University, Lubbock, TX 79409, USATexas Tech University, Lubbock, TX 79409, USATexas Tech University, Lubbock, TX 79409, USATexas Tech University, Lubbock, TX 79409, USASeverance and Associates, P.A., San Antonio, TX 78207, USATexas Tech Health Sciences Center, Lubbock, TX 79430, USATexas Tech Health Sciences Center, Lubbock, TX 79430, USARheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (MΦ) which could explain the perpetuation of inflammation associated with RA. A monoarticular arthritis was induced in female Lewis rats by injection of streptococcal cell wall extracts (PG-APS). After swelling and erythema subsided, joints were re-injected with one of the following: porcine MPO or partially inactivated MPO (iMPO). Injection with either MPO or iMPO induced a 'flare' of experimental RA. Blocking the MΦ-mannose receptor by mannans, ablated exacerbation of disease. These results indicate that MPO or iMPO can play a pivotal role in the perpetuation but not initiation of this RA model.http://dx.doi.org/10.1080/09629359890758AutoimmunityPeroxidasesTNFαRheumatoid arthritisReactive oxygen intermediates. |
| spellingShingle | Monique P. Gelderman Rodney Stuart David Vigerust Steven Fuhrmann Doris L. Lefkowitz Robert C. Allen Stanley S. Lefkowitz Susan Graham Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase Mediators of Inflammation Autoimmunity Peroxidases TNFα Rheumatoid arthritis Reactive oxygen intermediates. |
| title | Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase |
| title_full | Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase |
| title_fullStr | Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase |
| title_full_unstemmed | Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase |
| title_short | Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase |
| title_sort | perpetuation of inflammation associated with experimental arthritis the role of macrophage activation by neutrophilic myeloperoxidase |
| topic | Autoimmunity Peroxidases TNFα Rheumatoid arthritis Reactive oxygen intermediates. |
| url | http://dx.doi.org/10.1080/09629359890758 |
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