A<small.letters>po</small.letters>E Polymorphism is Associated With C-Reactive Protein in Low-HDL Family Members and in Normolipidemic Subjects
<p>The study was aimed to compare inflammatory parameters between carriers of apoE4 isoforms (apoE4/3, apoE4/2, and apoE4/4 phenotypes) and those of carrying apoE3 isoform without apoE4 isoform (apoE3/3 phenotypes and apoE2/3 phenotypes). The concentrations of serum hsCRP, sVCAM-1, sICAM-1, an...
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| Format: | Article |
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| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/12587 |
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| Summary: | <p>The study was aimed to compare inflammatory parameters between carriers of apoE4 isoforms (apoE4/3, apoE4/2, and apoE4/4 phenotypes) and those of carrying apoE3 isoform without apoE4 isoform (apoE3/3 phenotypes and apoE2/3 phenotypes). The concentrations of serum hsCRP, sVCAM-1, sICAM-1, and sE-selectin were measured in 211 subjects from Finnish low-HDL families and in 157 normolipidemic subjects. The subjects with apoE4 isoform had lower concentrations of serum hsCRP both in low-HDL family members (<mml:math> <mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn> </mml:math>) and in normolipidemic subjects (<mml:math> <mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.01</mml:mn> </mml:math>). The differences in serum CRP values remained significant after adjustment for age, BMI, smoking status, hypertension, gender, lipoprotein variables, and family number. We conclude that apoE phenotype has a strong influence on serum CRP values.</p> |
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| ISSN: | 0962-9351 |