Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of Gait
Introduction. The sequence effect (SE) is a reason contributing to freezing of gait (FOG) in Parkinson’s disease (PD) patients. There is no effective treatment for the SE. The objective of the current study is to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the SE...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2019/2196195 |
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| author | Jinghong Ma Linlin Gao Taomian Mi Junyan Sun Piu Chan Tao Wu |
| author_facet | Jinghong Ma Linlin Gao Taomian Mi Junyan Sun Piu Chan Tao Wu |
| author_sort | Jinghong Ma |
| collection | DOAJ |
| description | Introduction. The sequence effect (SE) is a reason contributing to freezing of gait (FOG) in Parkinson’s disease (PD) patients. There is no effective treatment for the SE. The objective of the current study is to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the SE in PD patients with FOG. Methods. 28 PD patients with FOG received either real or sham 10-Hz rTMS over the supplementary motor area (SMA). The effects of rTMS on the SE, FOG, and some gait parameters were evaluated. Results. rTMS did not improve the SE. Real rTMS had beneficial effects on FOG and some gait parameters, and this effect lasted for at least four weeks. Conclusions. High-frequency rTMS over the SMA cannot alleviate the SE in PD patients with FOG. rTMS has a long-lasting beneficial effect on FOG; however, this effect is not achieved by improving the SE but may be through improving some other gait parameters. |
| format | Article |
| id | doaj-art-d687c101b7b249fa92c8046da9a2b57a |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-d687c101b7b249fa92c8046da9a2b57a2025-02-03T01:09:54ZengWileyParkinson's Disease2090-80832042-00802019-01-01201910.1155/2019/21961952196195Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of GaitJinghong Ma0Linlin Gao1Taomian Mi2Junyan Sun3Piu Chan4Tao Wu5Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, ChinaDepartment of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, Beijing, ChinaDepartment of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, ChinaDepartment of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, ChinaIntroduction. The sequence effect (SE) is a reason contributing to freezing of gait (FOG) in Parkinson’s disease (PD) patients. There is no effective treatment for the SE. The objective of the current study is to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the SE in PD patients with FOG. Methods. 28 PD patients with FOG received either real or sham 10-Hz rTMS over the supplementary motor area (SMA). The effects of rTMS on the SE, FOG, and some gait parameters were evaluated. Results. rTMS did not improve the SE. Real rTMS had beneficial effects on FOG and some gait parameters, and this effect lasted for at least four weeks. Conclusions. High-frequency rTMS over the SMA cannot alleviate the SE in PD patients with FOG. rTMS has a long-lasting beneficial effect on FOG; however, this effect is not achieved by improving the SE but may be through improving some other gait parameters.http://dx.doi.org/10.1155/2019/2196195 |
| spellingShingle | Jinghong Ma Linlin Gao Taomian Mi Junyan Sun Piu Chan Tao Wu Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of Gait Parkinson's Disease |
| title | Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of Gait |
| title_full | Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of Gait |
| title_fullStr | Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of Gait |
| title_full_unstemmed | Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of Gait |
| title_short | Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of Gait |
| title_sort | repetitive transcranial magnetic stimulation does not improve the sequence effect in freezing of gait |
| url | http://dx.doi.org/10.1155/2019/2196195 |
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