Children and providers’ perspectives on once-weekly rifapentine and isoniazid TB preventive therapy
BACKGROUND: TB preventive treatment (TPT) prevents the development of TB disease in individuals at risk of progression from infection to disease. However, implementation of TPT for children is poor in most high-burden settings. The long duration and pill burden of the 6-month once-daily isoniazid re...
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| Format: | Article |
| Language: | English |
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International Union Against Tuberculosis and Lung Disease (The Union)
2025-01-01
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| Series: | IJTLD Open |
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| Online Access: | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000001/art00004 |
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| author | A.J. Marthinus D.T. Wademan Z. Saule Y. Hirsch-Moverman L. Viljoen J. Winckler L. van der Laan M. Palmer S.L. Barnabas R. Boyd A.C. Hesseling G. Hoddinott |
| author_facet | A.J. Marthinus D.T. Wademan Z. Saule Y. Hirsch-Moverman L. Viljoen J. Winckler L. van der Laan M. Palmer S.L. Barnabas R. Boyd A.C. Hesseling G. Hoddinott |
| author_sort | A.J. Marthinus |
| collection | DOAJ |
| description | BACKGROUND: TB preventive treatment (TPT) prevents the development of TB disease in individuals at risk of progression from infection to disease. However, implementation of TPT for children is poor in most high-burden settings. The long duration and pill burden of the 6-month once-daily isoniazid regimen (6H) pose significant barriers to completion. We aimed to understand children’s, caregivers’, and healthcare providers’ experiences of the 12-week once-weekly rifapentine and isoniazid (3HP) regimen using a dispersible tablet formulation in South Africa. METHODS: Serial, in-depth qualitative interviews with 20 child-caregiver dyads, including 5 children living with HIV (CLWH) and 9 healthcare providers across two study sites implementing a pharmacokinetic and safety trial of 3HP, were analysed deductively. RESULTS: Of those with experience using both 3HP and 6H, caregivers and healthcare providers preferred 3HP, and study participants reported that the 3HP formulation was more palatable and easier to prepare and administer. Caregivers and healthcare providers were concerned about optimally integrating 3HP into routine care, primarily due to its once-weekly administration. Children with HIV preferred the once-daily 6H regimen for its ease of use with their daily antiretroviral therapy. CONCLUSIONS: 3HP reduced the administration burden for children and their caregivers. Once weekly, 3HP dosing will require education and adherence support to ensure completion. |
| format | Article |
| id | doaj-art-d679bb89511b45328192eb8b5861b335 |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-d679bb89511b45328192eb8b5861b3352025-01-23T13:39:30ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902025-01-0121131810.5588/ijtldopen.24.02504Children and providers’ perspectives on once-weekly rifapentine and isoniazid TB preventive therapyA.J. Marthinus0D.T. Wademan1Z. Saule2Y. Hirsch-Moverman3L. Viljoen4J. Winckler5L. van der Laan6M. Palmer7S.L. Barnabas8R. Boyd9A.C. Hesseling10G. Hoddinott11Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;ICAP at Columbia University, Mailman School of Public Health, New York, NY, USA;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;FAMCRU, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;Division of Tuberculosis Elimination, Clinical Research Branch, Centers for Disease Control and Prevention, USA;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;BACKGROUND: TB preventive treatment (TPT) prevents the development of TB disease in individuals at risk of progression from infection to disease. However, implementation of TPT for children is poor in most high-burden settings. The long duration and pill burden of the 6-month once-daily isoniazid regimen (6H) pose significant barriers to completion. We aimed to understand children’s, caregivers’, and healthcare providers’ experiences of the 12-week once-weekly rifapentine and isoniazid (3HP) regimen using a dispersible tablet formulation in South Africa. METHODS: Serial, in-depth qualitative interviews with 20 child-caregiver dyads, including 5 children living with HIV (CLWH) and 9 healthcare providers across two study sites implementing a pharmacokinetic and safety trial of 3HP, were analysed deductively. RESULTS: Of those with experience using both 3HP and 6H, caregivers and healthcare providers preferred 3HP, and study participants reported that the 3HP formulation was more palatable and easier to prepare and administer. Caregivers and healthcare providers were concerned about optimally integrating 3HP into routine care, primarily due to its once-weekly administration. Children with HIV preferred the once-daily 6H regimen for its ease of use with their daily antiretroviral therapy. CONCLUSIONS: 3HP reduced the administration burden for children and their caregivers. Once weekly, 3HP dosing will require education and adherence support to ensure completion.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000001/art00004paediatric tbtuberculosisltbipreventioncontrol programmehiv |
| spellingShingle | A.J. Marthinus D.T. Wademan Z. Saule Y. Hirsch-Moverman L. Viljoen J. Winckler L. van der Laan M. Palmer S.L. Barnabas R. Boyd A.C. Hesseling G. Hoddinott Children and providers’ perspectives on once-weekly rifapentine and isoniazid TB preventive therapy IJTLD Open paediatric tb tuberculosis ltbi prevention control programme hiv |
| title | Children and providers’ perspectives on once-weekly rifapentine and isoniazid TB preventive therapy |
| title_full | Children and providers’ perspectives on once-weekly rifapentine and isoniazid TB preventive therapy |
| title_fullStr | Children and providers’ perspectives on once-weekly rifapentine and isoniazid TB preventive therapy |
| title_full_unstemmed | Children and providers’ perspectives on once-weekly rifapentine and isoniazid TB preventive therapy |
| title_short | Children and providers’ perspectives on once-weekly rifapentine and isoniazid TB preventive therapy |
| title_sort | children and providers perspectives on once weekly rifapentine and isoniazid tb preventive therapy |
| topic | paediatric tb tuberculosis ltbi prevention control programme hiv |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000001/art00004 |
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