The prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation: a systematic review

ObjectivesThis systematic review addressed the question: “What is the prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation?”Materials and MethodsA systematic search was conducted in MEDLINE/PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Grey Liter...

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Main Authors: Letícia Tainá de Oliveira Lemes, Carolina Horn Troian-Michel, Theodoro Weissheimer, Marcus Vinicius Reis Só
Format: Article
Language:English
Published: Korean Academy of Conservative Dentistry 2024-05-01
Series:Restorative Dentistry & Endodontics
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Online Access:http://www.rde.ac/upload/pdf/rde-49-e22.pdf
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author Letícia Tainá de Oliveira Lemes
Carolina Horn Troian-Michel
Theodoro Weissheimer
Marcus Vinicius Reis Só
author_facet Letícia Tainá de Oliveira Lemes
Carolina Horn Troian-Michel
Theodoro Weissheimer
Marcus Vinicius Reis Só
author_sort Letícia Tainá de Oliveira Lemes
collection DOAJ
description ObjectivesThis systematic review addressed the question: “What is the prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation?”Materials and MethodsA systematic search was conducted in MEDLINE/PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Grey Literature Report. Eligibility criteria were based on the condition, content, and population strategy: the condition was the radiographic prevalence of apical periodontitis, the content comprised patients scheduled for hematopoietic stem cell transplantation, and the population consisted of adult and pediatric patients. The revised Risk of Bias in Nonrandomized Studies of Exposure tool was used to assess the quality of studies. The Grading Recommendations Assessments, Development, and Evaluation (GRADE) tool was used to assess the quality of evidence.ResultsEight studies were included in this review. The average number of patients with apical periodontitis was 15.65% (range, 2.1%–43.34%). One study was classified as having a very high risk of bias, 1 with a high risk of bias, and 6 with some concern for bias. GRADE analysis showed a very low certainty of evidence. Significant limitations concerning the absence of control over confounding variables were identified.ConclusionsWith the caveat of the very low quality of evidence in the studies reviewed, there was a low to moderate prevalence of apical periodontitis in patients prior to undergoing hematopoietic cell transplantation.
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spelling doaj-art-d6798b2c6e4e42d2843020cf2dfd15dd2025-08-20T02:38:46ZengKorean Academy of Conservative DentistryRestorative Dentistry & Endodontics2234-76582234-76662024-05-01492e2210.5395/rde.2024.49.e221105The prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation: a systematic reviewLetícia Tainá de Oliveira LemesCarolina Horn Troian-MichelTheodoro WeissheimerMarcus Vinicius Reis SóObjectivesThis systematic review addressed the question: “What is the prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation?”Materials and MethodsA systematic search was conducted in MEDLINE/PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Grey Literature Report. Eligibility criteria were based on the condition, content, and population strategy: the condition was the radiographic prevalence of apical periodontitis, the content comprised patients scheduled for hematopoietic stem cell transplantation, and the population consisted of adult and pediatric patients. The revised Risk of Bias in Nonrandomized Studies of Exposure tool was used to assess the quality of studies. The Grading Recommendations Assessments, Development, and Evaluation (GRADE) tool was used to assess the quality of evidence.ResultsEight studies were included in this review. The average number of patients with apical periodontitis was 15.65% (range, 2.1%–43.34%). One study was classified as having a very high risk of bias, 1 with a high risk of bias, and 6 with some concern for bias. GRADE analysis showed a very low certainty of evidence. Significant limitations concerning the absence of control over confounding variables were identified.ConclusionsWith the caveat of the very low quality of evidence in the studies reviewed, there was a low to moderate prevalence of apical periodontitis in patients prior to undergoing hematopoietic cell transplantation.http://www.rde.ac/upload/pdf/rde-49-e22.pdfapical periodontitisbone marrow transplantendodonticshematopoietic stem cell transplantsystematic review
spellingShingle Letícia Tainá de Oliveira Lemes
Carolina Horn Troian-Michel
Theodoro Weissheimer
Marcus Vinicius Reis Só
The prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation: a systematic review
Restorative Dentistry & Endodontics
apical periodontitis
bone marrow transplant
endodontics
hematopoietic stem cell transplant
systematic review
title The prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation: a systematic review
title_full The prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation: a systematic review
title_fullStr The prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation: a systematic review
title_full_unstemmed The prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation: a systematic review
title_short The prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation: a systematic review
title_sort prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation a systematic review
topic apical periodontitis
bone marrow transplant
endodontics
hematopoietic stem cell transplant
systematic review
url http://www.rde.ac/upload/pdf/rde-49-e22.pdf
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