Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis
Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which wer...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/6567432 |
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| author | Beatriz Coutinho de Sousa Juliana Reis Machado Marcos Vinicius da Silva Thiago Alvares da Costa Javier Emilio Lazo-Chica Thatiane do Prado Degasperi Virmondes Rodrigues Junior Helioswilton Sales-Campos Elizabeth Uber Bucek Carlo José Freire Oliveira |
| author_facet | Beatriz Coutinho de Sousa Juliana Reis Machado Marcos Vinicius da Silva Thiago Alvares da Costa Javier Emilio Lazo-Chica Thatiane do Prado Degasperi Virmondes Rodrigues Junior Helioswilton Sales-Campos Elizabeth Uber Bucek Carlo José Freire Oliveira |
| author_sort | Beatriz Coutinho de Sousa |
| collection | DOAJ |
| description | Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate. Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF-α and IFN-γ, was also observed in the intestine. Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates. Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening. These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease. |
| format | Article |
| id | doaj-art-d6767b042fea4f2e8b41240d5dc35721 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d6767b042fea4f2e8b41240d5dc357212025-02-03T05:58:14ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/65674326567432Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental ColitisBeatriz Coutinho de Sousa0Juliana Reis Machado1Marcos Vinicius da Silva2Thiago Alvares da Costa3Javier Emilio Lazo-Chica4Thatiane do Prado Degasperi5Virmondes Rodrigues Junior6Helioswilton Sales-Campos7Elizabeth Uber Bucek8Carlo José Freire Oliveira9Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, BrazilInstitute of Tropical Pathology and Public Health, Federal University of Goias, 74605-050 Goiania, GO, BrazilInstitute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, BrazilInstitute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, BrazilInstitute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, BrazilInstitute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, BrazilInstitute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, BrazilInstitute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, BrazilDepartment of Pharmaceutical Sciences, University of Uberaba, 38050-501 Uberaba, MG, BrazilInstitute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, BrazilMorinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate. Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF-α and IFN-γ, was also observed in the intestine. Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates. Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening. These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease.http://dx.doi.org/10.1155/2017/6567432 |
| spellingShingle | Beatriz Coutinho de Sousa Juliana Reis Machado Marcos Vinicius da Silva Thiago Alvares da Costa Javier Emilio Lazo-Chica Thatiane do Prado Degasperi Virmondes Rodrigues Junior Helioswilton Sales-Campos Elizabeth Uber Bucek Carlo José Freire Oliveira Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis Mediators of Inflammation |
| title | Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
| title_full | Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
| title_fullStr | Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
| title_full_unstemmed | Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
| title_short | Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
| title_sort | morinda citrifolia noni fruit juice reduces inflammatory cytokines expression and contributes to the maintenance of intestinal mucosal integrity in dss experimental colitis |
| url | http://dx.doi.org/10.1155/2017/6567432 |
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