New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A

New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A

Introduction: Botulinum neurotoxins (BoNTs) cause botulism and are the most potent natural toxins known. Immunotherapy with neutralizing monoclonal antibodies (MAbs) is considered to be the most effective immediate response to BoNT exposure. Hybridoma technology remains the preferred method for prod...

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Main Authors: Marina Vladimirovna Silkina, Alena Sergeevna Kartseva, Alena Konstantinovna Riabko, Mariia Aleksandrovna Makarova, Metkhun Madibronovich Rogozin, Yana Olegovna Romanenko, Igor Georgievich Shemyakin, Ivan Alekseevich Dyatlov, Victoria Valerievna Firstova
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2024-07-01
Series:BioImpacts
Subjects:
botulism
botulinum neurotoxin
clostridium botulinum
snap25
human monoclonal antibody
k6h6/b5
Online Access:https://bi.tbzmed.ac.ir/PDF/bi-14-27680.pdf
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