Cannabinoids and the endocannabinoid system in liver diseases
Cannabinoids are biologically active substances acting via feedback-coupled CB1 and CB2 receptors. Their expression in myofibroblasts and liver endothelial cells is reported to be elevated in chronic liver diseases. The effect of CB1 receptor stimulation is to increase fibrosis and inflammatory acti...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-12-01
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| Series: | Clinical & Experimental Hepatology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Cannabinoids-and-the-endocannabinoid-system-in-liver-diseases,80,55209,1,1.html |
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| _version_ | 1832584892736602112 |
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| author | Anna Parfieniuk-Kowerda Diana Martonik Aleksandra Andrzejuk Aleksander Tarasik Robert Flisiak |
| author_facet | Anna Parfieniuk-Kowerda Diana Martonik Aleksandra Andrzejuk Aleksander Tarasik Robert Flisiak |
| author_sort | Anna Parfieniuk-Kowerda |
| collection | DOAJ |
| description | Cannabinoids are biologically active substances acting via feedback-coupled CB1 and CB2 receptors. Their expression in myofibroblasts and liver endothelial cells is reported to be elevated in chronic liver diseases. The effect of CB1 receptor stimulation is to increase fibrosis and inflammatory activity in the liver by stimulating stellate cells, while activation of the CB2 receptor results in inhibition of fibrosis. Stimulation of the CB1 receptor may also lead to progression of liver steatosis and carcinogenesis. In end-stage liver disease, the endocannabinoid system plays an important role in the pathogenesis of encephalopathy and vascular effects, such as portal hypertension, splanchnic vasodilatation and cirrhotic cardiomyopathy. It seems that interference in endocannabinoid transmission may serve as an attractive target for the development of hepatological drugs. |
| format | Article |
| id | doaj-art-d66a071156e44058a4155e9a96e1ab4f |
| institution | Kabale University |
| issn | 2392-1099 2449-8238 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Clinical & Experimental Hepatology |
| spelling | doaj-art-d66a071156e44058a4155e9a96e1ab4f2025-01-27T10:31:14ZengTermedia Publishing HouseClinical & Experimental Hepatology2392-10992449-82382024-12-0110421121710.5114/ceh.2024.14535855209Cannabinoids and the endocannabinoid system in liver diseasesAnna Parfieniuk-KowerdaDiana MartonikAleksandra AndrzejukAleksander TarasikRobert FlisiakCannabinoids are biologically active substances acting via feedback-coupled CB1 and CB2 receptors. Their expression in myofibroblasts and liver endothelial cells is reported to be elevated in chronic liver diseases. The effect of CB1 receptor stimulation is to increase fibrosis and inflammatory activity in the liver by stimulating stellate cells, while activation of the CB2 receptor results in inhibition of fibrosis. Stimulation of the CB1 receptor may also lead to progression of liver steatosis and carcinogenesis. In end-stage liver disease, the endocannabinoid system plays an important role in the pathogenesis of encephalopathy and vascular effects, such as portal hypertension, splanchnic vasodilatation and cirrhotic cardiomyopathy. It seems that interference in endocannabinoid transmission may serve as an attractive target for the development of hepatological drugs.https://www.termedia.pl/Cannabinoids-and-the-endocannabinoid-system-in-liver-diseases,80,55209,1,1.htmlliver diseases cannabinoids cb1 cb2 endocannabinoids |
| spellingShingle | Anna Parfieniuk-Kowerda Diana Martonik Aleksandra Andrzejuk Aleksander Tarasik Robert Flisiak Cannabinoids and the endocannabinoid system in liver diseases Clinical & Experimental Hepatology liver diseases cannabinoids cb1 cb2 endocannabinoids |
| title | Cannabinoids and the endocannabinoid system in liver diseases |
| title_full | Cannabinoids and the endocannabinoid system in liver diseases |
| title_fullStr | Cannabinoids and the endocannabinoid system in liver diseases |
| title_full_unstemmed | Cannabinoids and the endocannabinoid system in liver diseases |
| title_short | Cannabinoids and the endocannabinoid system in liver diseases |
| title_sort | cannabinoids and the endocannabinoid system in liver diseases |
| topic | liver diseases cannabinoids cb1 cb2 endocannabinoids |
| url | https://www.termedia.pl/Cannabinoids-and-the-endocannabinoid-system-in-liver-diseases,80,55209,1,1.html |
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