Influence of Maternal Immunization with Allergens on the Thymic Maturation of Lymphocytes with Regulatory Potential in Children: A Broad Field for Further Exploration
A variety of mechanisms are involved in the regulation of offspring allergy development through maternal immunization with allergens. The passive transfer of antigens, antibodies, and cytokines, the induction of phenotypic alterations in offspring lymphocytes, and the induction of regulatory populat...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/780386 |
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| author | Jefferson Russo Victor |
| author_facet | Jefferson Russo Victor |
| author_sort | Jefferson Russo Victor |
| collection | DOAJ |
| description | A variety of mechanisms are involved in the regulation of offspring allergy development through maternal immunization with allergens. The passive transfer of antigens, antibodies, and cytokines, the induction of phenotypic alterations in offspring lymphocytes, and the induction of regulatory populations in offspring have been proposed, but these mechanisms remain incompletely understood. It is likely that maternal immunization could affect the intrathymic maturation of offspring TCD4+, TCD8+, γδT, nTreg, iNKT, and B lymphocytes, although there are currently no human maternal immunization protocols for the regulation of allergic responses in children. Some studies have suggested a direct interaction between the maternal immune status and the offspring intrathymic microenvironment; this interaction could influence the maturation of offspring regulatory cells and must be explored for the development of therapies to control allergy development in children. |
| format | Article |
| id | doaj-art-d66633e508c04f4985f0823082fac9d4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d66633e508c04f4985f0823082fac9d42025-02-03T05:48:10ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/780386780386Influence of Maternal Immunization with Allergens on the Thymic Maturation of Lymphocytes with Regulatory Potential in Children: A Broad Field for Further ExplorationJefferson Russo Victor0Laboratory of Dermatology and Immunodeficiencies, LIM-56, Medical School, University of Sao Paulo, Avenida Dr. Eneas de Carvalho Aguiar 500, Third Floor, 05403-000 Sao Paulo, SP, BrazilA variety of mechanisms are involved in the regulation of offspring allergy development through maternal immunization with allergens. The passive transfer of antigens, antibodies, and cytokines, the induction of phenotypic alterations in offspring lymphocytes, and the induction of regulatory populations in offspring have been proposed, but these mechanisms remain incompletely understood. It is likely that maternal immunization could affect the intrathymic maturation of offspring TCD4+, TCD8+, γδT, nTreg, iNKT, and B lymphocytes, although there are currently no human maternal immunization protocols for the regulation of allergic responses in children. Some studies have suggested a direct interaction between the maternal immune status and the offspring intrathymic microenvironment; this interaction could influence the maturation of offspring regulatory cells and must be explored for the development of therapies to control allergy development in children.http://dx.doi.org/10.1155/2014/780386 |
| spellingShingle | Jefferson Russo Victor Influence of Maternal Immunization with Allergens on the Thymic Maturation of Lymphocytes with Regulatory Potential in Children: A Broad Field for Further Exploration Journal of Immunology Research |
| title | Influence of Maternal Immunization with Allergens on the Thymic Maturation of Lymphocytes with Regulatory Potential in Children: A Broad Field for Further Exploration |
| title_full | Influence of Maternal Immunization with Allergens on the Thymic Maturation of Lymphocytes with Regulatory Potential in Children: A Broad Field for Further Exploration |
| title_fullStr | Influence of Maternal Immunization with Allergens on the Thymic Maturation of Lymphocytes with Regulatory Potential in Children: A Broad Field for Further Exploration |
| title_full_unstemmed | Influence of Maternal Immunization with Allergens on the Thymic Maturation of Lymphocytes with Regulatory Potential in Children: A Broad Field for Further Exploration |
| title_short | Influence of Maternal Immunization with Allergens on the Thymic Maturation of Lymphocytes with Regulatory Potential in Children: A Broad Field for Further Exploration |
| title_sort | influence of maternal immunization with allergens on the thymic maturation of lymphocytes with regulatory potential in children a broad field for further exploration |
| url | http://dx.doi.org/10.1155/2014/780386 |
| work_keys_str_mv | AT jeffersonrussovictor influenceofmaternalimmunizationwithallergensonthethymicmaturationoflymphocyteswithregulatorypotentialinchildrenabroadfieldforfurtherexploration |